DC Chemicals · Product datasheet

N-Desmethyl Pimavanserin — Datasheet

CAT. NO. DC28845

Product page and current package options

ParameterValue
Chemical NameN-Desmethyl Pimavanserin
CAS No.639863-77-7
SynonymsCXL6LOR95E;N-Desmethyl-pimavanserin;n-(4-fluorobenzyl)-n-(piperidin-4-yl)-n'-(4-isobutyloxybenzyl)carbamide;Urea, N-((4-fluorophenyl)methyl)-N'-((4-(2-methylpropoxy)phenyl)methyl)-N-4-piperidinyl-;Unii-cxl6lor95E;AC-279;N-Desmethyl Pimavanserin
FormulaC24H32FN3O2
M.Wt413.528189659119
SMILESFC1C=CC(=CC=1)CN(C(NCC1C=CC(=CC=1)OCC(C)C)=O)C1CCNCC1
Purity>98%
Storage2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological Activity

N-Desmethyl Pimavanserin is the active metabolite of Pimavanserin. Pimavanserin is a selective inverse agonist of the 5-HT2A receptor with pIC50 and pKd of 8.73 and 9.3, respectively.

In Vitro

The mean plasma half-lives for Pimavanserin and its metabolite N-Desmethyl Pimavanserin (AC-279) are 57 hours and 200 hours, respectively.

In Vivo

No in vivo data are provided in the current product source. Contact us for further information.

References & source

[1]. Vanover KE, et al. Pharmacological and behavioral profile of N-(4-fluorophenylmethyl)-N-(1-methylpiperidin-4-yl)-N'-(4-(2-methylpropyloxy)phenylmethyl) carbamide (2R,3R)-dihydroxybutanedioate (2:1) (ACP-103), a novel 5-hydroxytryptamine(2A) receptor inverse agonist. J Pharmacol Exp Ther. 2006 May;317(2):910-8.

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.

Cart

Request quotation