For research use only. We do not sell to patients.
Ionizable lipids / 6Ac1-C12
6Ac1-C12 chemical structure
Product imageResearch use only
CAT. NO. DC60809Featured

6Ac1-C12

Ionizable lipid for LNP and nucleic-acid delivery research.

Pack size & price

USD
TotalUS$600
We match the best price and quality on market.
Ships from ShanghaiIce-pack transportPure lipid recommended
Product overview

Description & Application

6Ac1-C12 is an ionizable cationic lipid with a hexaester degradable core and six C12 hydrophobic alkyl tails, featuring a pKa around 6.0 and strong endosomal escape capacity. Its four-component LNPs deliver mRNA mainly to liver endothelial cells after IV injection and remain stable for 30 days at 4°C. Formulated without cholesterol, its three-component system enables lung-targeted delivery with low in vivo toxicity, and the ester core facilitates biodegradation for versatile mRNA applications.

CAS No.Not available
Chemical Name6Ac1-C12
Synonyms6Ac1C12，， 6Ac1 C12
SMILESCCCCCCCCCCCCNCCC(=O)OCC(COCC(COC(=O)CCN(C)CCCCCCCCCCCC)(COC(=O)CCN(C)CCCCCCCCCCCC)COC(=O)CCN(C)CCCCCCCCCCCC)(COC(=O)CCN(C)CCCCCCCCCCCC)OC(=O)CCN(C)CCCCCCCCCCCC
FormulaC104H204O13N6
M.Wt1,746.81
PurityELSD-HPLC>95%
StoragePure form: −20 °C, 1 year; In solvent: −80 °C, 6 months; −20 °C, 1 month. Sealed and protected from light.
Shipping conditionShips from Shanghai. Pure lipid is stable during ice-pack transport.
PublicationGAO X, et al. Reformulating lipid nanoparticles for organ-targeted mRNA accumulation and translation[J]. Nature Communications, 2024, 15(1): 5740.
Laboratory planning

Solution Calculators

The product molecular weight is prefilled when available and remains editable. Confirm solvent compatibility and solubility before preparation.

Mass = concentration × volume × molecular weight
Enter any three values to calculate the fourth.
C₁V₁ = C₂V₂
Enter any three values to calculate the fourth.
Preparing stock solutions

Quick preparation table

Solvent volumes update from the molecular weight above.

Mass1 mM5 mM10 mM
10 mg5.7247 mL1.1449 mL572.47 μL
25 mg14.3118 mL2.8624 mL1.4312 mL
50 mg28.6236 mL5.7247 mL2.8624 mL
100 mg57.2472 mL11.4494 mL5.7247 mL
250 mg143.1180 mL28.6236 mL14.3118 mL

Need a different pack size or technical document?

Contact our team with the catalog number and requested quantity.

Contact us
Handling guidance

Shipping, storage and sampling

How is the lipid shipped, and how should I store it?
We generally ship the neat (undissolved) lipid compound rather than an ethanol solution. The neat lipid is stable during transport with ice packs, and shipments originate from Shanghai. Pure form: store at −20 °C for up to 1 year. In solvent: store at −80 °C for up to 6 months or at −20 °C for up to 1 month. Keep sealed and protected from light. Avoid repeated thaw cycles for best results.
Pure lipid or solution — which should I choose?
Pure lipid is generally more stable during shipping and storage, so we usually recommend the pure form. A solution in ethanol or chloroform can be supplied when required by your workflow. Tell us the intended application, solvent and target concentration so the most suitable format can be confirmed.
How should I measure a small amount of oily or viscous lipid?
Ionizable lipids are often oily liquids or viscous semisolids, so material can be lost during repeated weighing or transfer. For a small pack, dissolve the entire quantity and aliquot it volumetrically. For example, add 1 mL ethanol to 25 mg lipid to prepare a 25 mg/mL stock, then use a pipette to withdraw the required amount. For quantities above 100 mg, direct weighing with an analytical balance may be more practical. Always confirm solvent compatibility and solubility first.
Can you support formulation optimization and scale-up?
Yes. Share the RNA cargo, target tissue, administration route, formulation method and assay plan. Our team can discuss starting molar ratios, N/P ratio and scale-up requirements for research workflows.