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6Ac1-C12

Version 1.c68acc53 · 2026-09-13

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CAS No.Not available
Chemical Name6Ac1-C12
Synonyms6Ac1C12，， 6Ac1 C12
SMILESCCCCCCCCCCCCNCCC(=O)OCC(COCC(COC(=O)CCN(C)CCCCCCCCCCCC)(COC(=O)CCN(C)CCCCCCCCCCCC)COC(=O)CCN(C)CCCCCCCCCCCC)(COC(=O)CCN(C)CCCCCCCCCCCC)OC(=O)CCN(C)CCCCCCCCCCCC
FormulaC104H204O13N6
M.Wt1,746.81
PurityELSD-HPLC>95%
StorageOriginal product: up to 1 year under the storage conditions stated on the vial, kept tightly sealed. Stock solutions: aliquots at -20°C, generally up to one month.
Shipping conditionShips from Shanghai. Pure lipid is stable during ice-pack transport.
PublicationGAO X, et al. Reformulating lipid nanoparticles for organ-targeted mRNA accumulation and translation[J]. Nature Communications, 2024, 15(1): 5740.

6Ac1-C12 is an ionizable cationic lipid with a hexaester degradable core and six C12 hydrophobic alkyl tails, featuring a pKa around 6.0 and strong endosomal escape capacity. Its four-component LNPs deliver mRNA mainly to liver endothelial cells after IV injection and remain stable for 30 days at 4°C. Formulated without cholesterol, its three-component system enables lung-targeted delivery with low in vivo toxicity, and the ester core facilitates biodegradation for versatile mRNA applications.

Specifications shown are product-page values, not batch test results.

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