DC Chemicals

DC60809 · Updated 28 October 2026

6Ac1-C12

Instructions for Use

Before use

Check the supplied lot number, batch COA, approved SDS, quantity and retest date. Pure form: −20 °C, 1 year; In solvent: −80 °C, 6 months; −20 °C, 1 month. Sealed and protected from light.

For small quantities of viscous or oily lipid, volumetric transfer can reduce weighing losses. Confirm solvent compatibility and solubility before preparing a stock; calculated volumes do not establish solubility.

Stock-solution planning

Volume (mL) = mass (mg) × 1000 / [molecular weight × concentration (mM)].

Mass10 mM20 mM
10 mg0.5634 mL0.2817 mL
25 mg1.4086 mL0.7043 mL
50 mg2.8171 mL1.4086 mL
100 mg5.6342 mL2.8171 mL

Literature formulation reference

ComponentDC Chemicals productMolecular weightMolar ratioMass at 1 µmol total lipid (mg)
6Ac1-C12DC608091774.86150.429402
DOPEDC33634744.03200.240010
CholesterolDCD-041386.65250.155907
DMG-PEG2000DC40169250720.080871

Relative molar parts, not percentages. 6Ac1-C12:mRNA mass ratio 10:1; this is not total lipid:mRNA or N/P. Main p.9; SI pp.2–4. DMG-PEG2000 uses 2507 for the catalog conversion.

Read the complete study conditions, biological results, tolerability and figures →

References

  1. Su K, Shi L, Sheng T et al. Reformulating lipid nanoparticles for organ-targeted mRNA accumulation and translation. Nature Communications 15, 5659 (2024). DOI: 10.1038/s41467-024-50093-7
  2. Author Source Data workbook; particle and biological endpoint data