DOPE, also known as 1,2-Dioleoyl-sn-glycero-3-PE or 1,2-DOPE, is a synthetic analog of naturally-occurring PE containing 18:1 fatty acids at the sn-1 and sn-2 positions. 1,2-DOPE can be used as an emulsifier to facilitate DNA-liposome complex transport across membranes. It is used in combination with cationic phospholipids to increase efficiency during DNA transfection studies as a non-viral method of gene delivery.
| CAS No. | 4004-05-1 |
| Chemical Name | 2-Aminoethyl (R)-2,3-Bis(oleoyloxy)propyl Hydrogen Phosphate |
| Synonyms | DOPE; 1,2-Dioleoyl-sn-glycero-3-Phosphoethanolamine; 1,2-DOPE; |
| SMILES | O=P(OC[C@H](OC(CCCCCCC/C=C\CCCCCCCC)=O)COC(CCCCCCC/C=C\CCCCCCCC)=O)(OCCN)O |
| Formula | C41H78NO8P |
| M.Wt | 744.0478 |
| Purity | >95% |
| Storage | -20 |
| Shipping condition | Ships from Shanghai; packaging confirmed at order. |
| Publication | Not available |
| Product classification | Helper lipids |
The product molecular weight is prefilled when available and remains editable. Confirm solvent compatibility and solubility before preparation.
Solvent volumes update from the molecular weight above.
| Mass | 1 mM | 5 mM | 10 mM |
|---|---|---|---|
| 10 mg | 13.4400 mL | 2.6880 mL | 1.3440 mL |
| 25 mg | 33.6000 mL | 6.7200 mL | 3.3600 mL |
| 50 mg | 67.2000 mL | 13.4400 mL | 6.7200 mL |
| 100 mg | 134.4000 mL | 26.8800 mL | 13.4400 mL |
| 250 mg | 335.9999 mL | 67.2000 mL | 33.6000 mL |
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