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CAT. NO. DC60605Featured

Lipid 119-23

Research highlights

584-lipid discovery library and 40,000-lipid virtual screen119-23 outperformed benchmark lipids in the reported muscle and immune-cell assaysClassic four-component and lung-targeted SORT formulations were characterized in the public SI

Pack size & price

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Total$500

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Ships from ShanghaiIce-pack transportPure lipid recommended

Product overview

Description & Application

Lipid 119-23 is an ionizable lipid for mRNA delivery. 119-23 LNP exhibits an enhanced capability to express functional mCre in several categories of immune cells, spanning the liver, spleen and lung.

CAS No.	2953044-98-7
Chemical Name	Lipid 119-23
Synonyms	Lipid 119 23
SMILES	CCCCCCCC/C=C\CCCCCCCC(N(C(CCCCCOC(CCCCCCC/C=C\CCCCCCCC)=O)C(NC1(C[C@@H](C2)C3)CC3CC2C1)=O)CCCN(C)C)=O
Formula	C58H105N3O4
M.Wt	908.47
Purity	>95% by ELSD-HPLC
Storage	Pure form: −20 °C, 1 year; In solvent: −80 °C, 6 months; −20 °C, 1 month. Sealed and protected from light.
Shipping condition	Ships from Shanghai. Pure lipid is stable during ice-pack transport.
Publication	Li B, Raji IO, Gordon AGR, et al. Accelerating ionizable lipid discovery for mRNA delivery using machine learning and combinatorial chemistry. Nat Mater. 2024;23:1002-1008.

Literature-reported formulation composition

Component	mol%	Role
119-23	Not reported	Ionizable lipid
DOPE	Not reported	helper_lipid
Cholesterol	Not reported	Sterol
C14-PEG	Not reported	PEG lipid
Reported total	Not reported	Source values retained

Formulation calculator unavailable. The supplied article does not report the complete molar composition, so a formulation weight calculation is not available. Obtain and verify the complete composition and component molecular weights before planning component quantities.

N/P ratioNot reported in the cited article

CargomLuc or hEPO mRNA; mCre reporter experiments are described in the SI figures

Administration routeIntramuscular and intravenous in mice; lung-targeted SORT five-component formulations were also tested intravenously.

Dose0.1 mg/kg mRNA per mouse for selected-lipid screening; 0.25 mg/kg mRNA per mouse for variant, liver/spleen and lung experiments.

Animal modelMouse mRNA expression and immune/endothelial-cell assays.

Formulation processClassic four-component formulation is identified in the SI figure captions; detailed article methods are subscription-restricted and no exact mixing recipe is inferred.

Literature-reported performance for the cited formulation

Literature-reportedDiscovery and benchmark comparison119-23 is identified as outperforming established benchmark lipids in muscle and immune-cell transfection in the publicly visible article abstract.Article-level summary; exact numerical values are not reconstructed from the abstractNature Materials abstract

Literature-reportedParticle characterization95 ± 1.5 nm; PDI 0.12 ± 0.02; EE 85.6%Classic four-component 119-23 LNPSI Supplementary Figure 9, public PDF page 18

Literature-reportedSORT particle characterization88 ± 0.01 nm; PDI 0.22 ± 0.01; EE 86.4%119-23 lung-targeted SORT five-component LNPSI Supplementary Figure 9, public PDF page 18

Literature-reportedhEPO expressionSerum hEPO was quantified after IV dosing; the SI reports a significant difference for the 119-23/SM-102 comparison (P = 0.0435) and a non-significant 119-23/MC3 comparison (P = 0.9744).0.25 mg/kg hEPO mRNA; n = 3SI Supplementary Figure 7, public PDF page 17

Literature Data DisclaimerAll formulation parameters and performance values shown in this section are derived from the cited publication and are provided for reference only. These results were obtained using the specific materials, formulation process, cargo, dose, analytical method, model and administration route described in that study. Unless otherwise stated, the data were not generated or independently verified by DC Chemicals. DC Chemicals supplies the lipid compound only and does not guarantee that customers will reproduce the reported LNP properties or biological performance.

The administration route shown above was used in the cited study and is not a clinical-use instruction or recommendation by DC Chemicals.

Cited literature for this formulation and performance datasetLi B, Raji IO, Gordon AGR, et al. Accelerating ionizable lipid discovery for mRNA delivery using machine learning and combinatorial chemistry. Nat Mater. 2024;23:1002-1008.
Formulation and performance source locations are listed with the evidence items above.

Nature article · DOI · Supplementary Information

Laboratory planning

Solution Calculators

The product molecular weight is prefilled when available and remains editable. Confirm solvent compatibility and solubility before preparation.

Mass = concentration × volume × molecular weight

MassConcentrationVolumeMolecular weightg/mol

Enter any three values to calculate the fourth.

C₁V₁ = C₂V₂

C₁mMV₁mLC₂mMV₂mL

Enter any three values to calculate the fourth.

Preparing stock solutions

Quick preparation table

Solvent volumes update from the molecular weight above.

Mass	1 mM	5 mM	10 mM
10 mg	11.0075 mL	2.2015 mL	1.1008 mL
25 mg	27.5188 mL	5.5038 mL	2.7519 mL
50 mg	55.0376 mL	11.0075 mL	5.5038 mL
100 mg	110.0752 mL	22.0150 mL	11.0075 mL
250 mg	275.1880 mL	55.0376 mL	27.5188 mL

Need a different pack size or technical document?

Contact our team with the catalog number and requested quantity.

Handling guidance

Shipping, storage and sampling

How is the lipid shipped, and how should I store it?

We generally ship the neat (undissolved) lipid compound rather than an ethanol solution. The neat lipid is stable during transport with ice packs, and shipments originate from Shanghai. Pure form: store at −20 °C for up to 1 year. In solvent: store at −80 °C for up to 6 months or at −20 °C for up to 1 month. Keep sealed and protected from light. Avoid repeated thaw cycles for best results.

Pure lipid or solution — which should I choose?

Pure lipid is generally more stable during shipping and storage, so we usually recommend the pure form. A solution in ethanol or chloroform can be supplied when required by your workflow. Tell us the intended application, solvent and target concentration so the most suitable format can be confirmed.

How should I measure a small amount of oily or viscous lipid?

Ionizable lipids are often oily liquids or viscous semisolids, so material can be lost during repeated weighing or transfer. For a small pack, dissolve the entire quantity and aliquot it volumetrically. For example, add 1 mL ethanol to 25 mg lipid to prepare a 25 mg/mL stock, then use a pipette to withdraw the required amount. For quantities above 100 mg, direct weighing with an analytical balance may be more practical. Always confirm solvent compatibility and solubility first.

Can you support formulation optimization and scale-up?

Yes. Share the RNA cargo, target tissue, administration route, formulation method and assay plan. Our team can discuss starting molar ratios, N/P ratio and scale-up requirements for research workflows.

Lipid 119-23

Pack size & price

Description & Application

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