5A2-SC8
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Ionizable lipid for LNP and nucleic-acid delivery research.
Si5-N14 is a lipid-based molecule engineered with siloxane groups, designed specifically for efficient mRNA delivery to the lungs. The incorporation of siloxane units boosts the cellular uptake of mRNA-loaded lipid nanoparticles (LNPs) and enhances their ability to escape from endosomes. These properties significantly increase the overall effectiveness of mRNA delivery, making Si5-N14 a promising tool for targeted therapeutic applications.
| CAS No. | Not available |
| Chemical Name | Si5-N14 |
| Synonyms | Si5N14, Si5 N14 |
| SMILES | O=C(CCN(CCC[Si](C)(C)O[Si](C)(CCCN(CCC(NCCCCCCCCCCCCCC)=O)CCC(NCCCCCCCCCCCCCC)=O)C)CCC(NCCCCCCCCCCCCCC)=O)NCCCCCCCCCCCCCC |
| Formula | C78H160N6O5Si2 |
| M.Wt | 1,318.3 |
| Purity | ELSD-HPLC>95% |
| Storage | Pure form: −20 °C, 1 year; In solvent: −80 °C, 6 months; −20 °C, 1 month. Sealed and protected from light. |
| Shipping condition | Ships from Shanghai. Pure lipid is stable during ice-pack transport. |
| Publication | Combinatorial design of siloxane-incorporated lipid nanoparticles augments intracellular processing for tissue-specific mRNA therapeutic delivery-Michael J. Mitchell -Nature Nanotechnology (2024) |
The product molecular weight is prefilled when available and remains editable. Confirm solvent compatibility and solubility before preparation.
Solvent volumes update from the molecular weight above.
| Mass | 1 mM | 5 mM | 10 mM |
|---|---|---|---|
| 10 mg | 7.5855 mL | 1.5171 mL | 758.55 μL |
| 25 mg | 18.9638 mL | 3.7928 mL | 1.8964 mL |
| 50 mg | 37.9276 mL | 7.5855 mL | 3.7928 mL |
| 100 mg | 75.8553 mL | 15.1711 mL | 7.5855 mL |
| 250 mg | 189.6382 mL | 37.9276 mL | 18.9638 mL |
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