5A2-SC8
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Ionizable lipid for LNP and nucleic-acid delivery research.
PPZ-A10 is an ionizable cationic lipid.It has been used in the generation of lipid nanoparticles (LNPs) for the delivery of siRNA and mRNA in vitro and in vivo. Intraperitoneal administration of LNPs containing PPZ-A10 and encapsulating an mRNA reporter preferentially accumulates in hepatic Kupffer cells and splenic macrophages in mice.
| CAS No. | Not available |
| Chemical Name | PPZ-A10 |
| Synonyms | N,N'-(piperazine-1,4-diylbis(propane-3,1-diyl))bis(3-(didecylamino)propanamide);PPZA10, PPZ A10 |
| SMILES | O=C(CCN(CCCCCCCCCC)CCCCCCCCCC)NCCCN1CCN(CCCNC(CCN(CCCCCCCCCC)CCCCCCCCCC)=O)CC1 |
| Formula | C56H114N6O2 |
| M.Wt | 903.6 |
| Purity | ELSD-HPLC>95% |
| Storage | Pure form: −20 °C, 1 year; In solvent: −80 °C, 6 months; −20 °C, 1 month. Sealed and protected from light. |
| Shipping condition | Ships from Shanghai. Pure lipid is stable during ice-pack transport. |
| Publication | 1. Subhan, M.A., and Torchilin, V.P. Biopolymer-based nanosystems for siRNA drug delivery to solid tumors including breast cancer. Pharmaceutics 15(1), 153 (2023). 2. Ni, H., Hatit, M.Z.C., Zhao, K., et al. Piperazine-derived lipid nanoparticles deliver mRNA to immune cells in vivo. Nat. Commun. 13(1), 4766 (2022). |
The product molecular weight is prefilled when available and remains editable. Confirm solvent compatibility and solubility before preparation.
Solvent volumes update from the molecular weight above.
| Mass | 1 mM | 5 mM | 10 mM |
|---|---|---|---|
| 10 mg | 11.0668 mL | 2.2134 mL | 1.1067 mL |
| 25 mg | 27.6671 mL | 5.5334 mL | 2.7667 mL |
| 50 mg | 55.3342 mL | 11.0668 mL | 5.5334 mL |
| 100 mg | 110.6684 mL | 22.1337 mL | 11.0668 mL |
| 250 mg | 276.6711 mL | 55.3342 mL | 27.6671 mL |
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