Literature-reported formulation composition
Component: PPZ-A10 | mol%: 35 | Role: Ionizable lipid
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PPZ-A10
Literature records
Search the tables and observations reproduced from the product literature guide. Rows may represent measurements, recipes or experimental context; they are not all independent experiments.
Literature-reported formulation composition
Component: Cholesterol | mol%: 46.5 | Role: Sterol
Literature-reported formulation composition
Component: C18PEG2K | mol%: 2.5 | Role: PEG lipid
Literature-reported formulation composition
Component: DOPE | mol%: 16 | Role: Helper phospholipid
Literature-reported formulation composition
Component: Reported total | mol%: 100 | Role: Source values retained
Reported observation
Literature-reported Cre mRNA delivery Approximately 60% tdTomato-positive Kupffer cells LNP-A10, 1 mg/kg IV, 3 days · Other liver and spleen cell populations in the same experiment PDF p. 5, Fig. 3c-d.
Reported observation
Literature-reported Cre mRNA delivery Approximately 50% tdTomato-positive splenic macrophages LNP-A10, 1 mg/kg IV, 3 days · Other liver and spleen cell populations in the same experiment PDF p. 5, Fig. 3c-d.
Reported observation
Literature-reported Cre mRNA delivery Approximately 30% tdTomato-positive splenic dendritic cells; approximately 20% liver dendritic cells LNP-A10, 1 mg/kg IV, 3 days · Other measured cell populations PDF p. 5, Fig. 3c-d.
Reported observation
Literature-reported Dose response Delivery remained measurable at 0.3 mg/kg LNP-A10 Cre mRNA, IV · 1 and 0.5 mg/kg groups PDF p. 5, Fig. 3e.
Reported observation
Literature-reported GFP silencing Approximately 25% reduction in GFP protein signal in Kupffer cells LNP-A10 siGFP versus siLuc, 1 mg/kg · siLuc control PDF p. 6, Fig. 3f.
Reported observation
Immune-cell tropism The pooled 65-LNP screen ranked PPZ-A10 among the highest-performing formulations for delivery to liver and splenic immune-cell populations; no lung delivery was observed in the screen. · PDF pp. 2-5, Fig. 2.