CICL-238
Recommended because it shares a closely related research category or delivery context. Formulation and performance are product- and study-specific.
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Ionizable lipid for LNP and nucleic-acid delivery research.
YSK 12C4 is an ionizable cationic lipid primarily used to enhance siRNA cellular delivery via multifunctional envelope-type nanodevices (MEND). YSK 12C4 promotes siRNA uptake and endosomal escape, effectively silencing genes in human immune cell lines.
| CAS No. | Not available |
| Chemical Name | YSK12-C4 (YSK12-MEND) |
| Synonyms | 6,9,28,31-Heptatriacontatetraen-19-ol, 19-[4-(dimethylamino)butyl]-, (6Z,9Z,28Z,31Z)-;YSK12C4, YSK12 C4 |
| SMILES | CCCCC/C=C\C/C=C\CCCCCCCCC(CCCCN(C)C)(O)CCCCCCCC/C=C\C/C=C\CCCCC |
| Formula | C43H81NO |
| M.Wt | 628.109353780746 |
| Purity | ELSD-HPLC>95% |
| Storage | Pure form: −20 °C, 1 year; In solvent: −80 °C, 6 months; −20 °C, 1 month. Sealed and protected from light. |
| Shipping condition | Ships from Shanghai. Pure lipid is stable during ice-pack transport. |
| Publication | Nakamura T, et al. Small-sized, stable lipid nanoparticle for the efficient delivery of siRNA to human immune cell lines. Sci Rep. 2016 Nov 28;6:37849. |
The product molecular weight is prefilled when available and remains editable. Confirm solvent compatibility and solubility before preparation.
Solvent volumes update from the molecular weight above.
| Mass | 1 mM | 5 mM | 10 mM |
|---|---|---|---|
| 10 mg | 15.9208 mL | 3.1842 mL | 1.5921 mL |
| 25 mg | 39.8020 mL | 7.9604 mL | 3.9802 mL |
| 50 mg | 79.6040 mL | 15.9208 mL | 7.9604 mL |
| 100 mg | 159.2079 mL | 31.8416 mL | 15.9208 mL |
| 250 mg | 398.0199 mL | 79.6040 mL | 39.8020 mL |
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