For research use only. We do not sell to patients.
Ionizable lipids / L-369
L-369 chemical structure
Product imageResearch use only
CAT. NO. DC65701Featured

L-369

Pack size & price

USD
TotalUS$550
We match the best price and quality on market.
Ships from ShanghaiIce-pack transportPure lipid recommended
Product overview

Description & Application

L-369 is a biodegradable ionizable lipid corresponding to Compound 17 in WO2013086354A1. The patent reports its evaluation in a Factor VII siRNA-LNP mouse screen and formulation particle-size measurements. Compound-specific clinical performance and a nonhuman-primate safety margin are not established by this source.

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Literature evidence · DC65701

Formulation & Performance

The primary patent supports a bounded hepatic siRNA-delivery record. Compound 17 is assigned to an ED50 interval rather than an exact potency value; particle and silencing results apply to the complete LNP.

The catalog connectivity was matched to Compound 17 in WO2013086354A1, rather than the same-formula isomer Compound 22. The neutral formula is C49H95NO6.

Formulation components and molecular-weight conversion

ComponentDC Chemicals productMolecular weightMolar ratioMass at 1 µmol total lipid (mg)
L-369 / Compound 17DC65701794.28500.397140
DSPCDC57005790.15100.079015
CholesterolDCD-041386.6538.50.148860
PEG-DMGDC4016925071.50.037605

Example 35 reports ionizable lipid:DSPC:cholesterol:PEG-DMG = 50:10:38.5:1.5 mol%. No unique Compound 17 N/P or lipid:siRNA mass ratio was identified. PEG-DMG mass conversion uses the catalog convention 2507.

Component mass calculator

Prefilled proportions follow the source specified above. Molecular weights and ratios are editable. Results are calculated, not measured study data. No N/P or RNA dose is inferred.

ComponentMWMolar ratioMass (mg)Mass %
L-369 / Compound 17——
DSPC——
Cholesterol——
PEG-DMG——

Formulation evidence

RecordReported resultInterpretation
PayloadAD-1661 siRNA targeting Factor VIIHepatic gene-silencing model
Lipid compositionCompound 17:DSPC:cholesterol:PEG-DMG = 50:10:38.5:1.5 mol%Example 35
Preparation approachIn-line mixing followed by buffer exchangeReported experimental approach, not validated manufacturing instructions
N/P and lipid:siRNA mass ratioNot established for the specific Compound 17 recordDo not infer from general LNP conventions

WO2013086354A1, Example 35; printed p202 onward.

Mouse Factor VII silencing

RecordReported resultInterpretation
ModelFemale C57BL/6 mice, 7–9 weeks; n=3 per groupExample 36
Administration / timingIntravenous; Factor VII readout at 24 hComplete siRNA-LNP formulation
Initial screen0.1, 0.3, 1.0 and 5.0 mg/kg siRNA; active formulations retested at lower rangesScreen design, not a dosing recommendation
Compound 17 potencyED50 bin 0.001–0.10 mg/kg, designated **An interval, not a precise ED50
Endpoint50% reduction in circulating Factor VII relative to controlGene silencing, not disease-model efficacy
ControlsPBS and benchmark formulationsNo exact superiority claim inferred

WO2013086354A1, Example 36. Compound 17 row: printed p207 / PDF p208 in the archived visual review.

Particles and evidence limits

RecordReported resultInterpretation
Diameter56 nm before and 56 nm after overnight dialysisExample 37 exact structure row; no uncertainty supplied
StabilityNo reported diameter change during dialysisNot long-term shelf life, serum or freeze–thaw stability
Other parametersCompound-specific PDI, encapsulation, zeta potential and apparent pKa not establishedLeave unavailable values blank
Tolerability and NHPNo Compound 17-specific NHP or wide-safety-margin dataset identifiedBroad patent embodiments are not verified Compound 17 findings
Evidence typePublic primary patentNot clinical validation

WO2013086354A1, Example 37, printed p209 / PDF p210. Synthesis and chemical analytical measurements are omitted from this public summary.

References and source locations

  1. Maier M, Jayaraman M, Akinc A, et al. WO2013086354A1. Biodegradable lipids for the delivery of active agents. 13 June 2013. Compound 17; Examples 35–37.
CAS No.1443522-24-4
Chemical NameL-369
SynonymsL369， L 369，Lipid 369, Lipid369
SMILESC(OCCC(CCCCC)CCCCC)(=O)CCCCCCCC(OC(=O)CCCN(C)C)CCCCCCCC(OCCC(CCCCC)CCCCC)=O
FormulaC49H95NO6
M.Wt794.28
Purity>95% by ELSD-HPLC
StoragePure form: −20 °C, 1 year; In solvent: −80 °C, 6 months; −20 °C, 1 month. Sealed and protected from light.
Shipping conditionShips from Shanghai. Pure lipid is stable during ice-pack transport.
Publication
  1. Maier M, Jayaraman M, Akinc A, et al. WO2013086354A1. Biodegradable lipids for the delivery of active agents. 13 June 2013. Compound 17; Examples 35–37.
F&PFormulation & PerformanceComposition, study results and referencesRead online →
Laboratory planning

Solution Calculators

The product molecular weight is prefilled when available and remains editable. Confirm solvent compatibility and solubility before preparation.

Mass = concentration × volume × molecular weight
Enter any three values to calculate the fourth.
C₁V₁ = C₂V₂
Enter any three values to calculate the fourth.
Preparing stock solutions

Quick preparation table

Solvent volumes update from the molecular weight above.

Mass1 mM5 mM10 mM
10 mg12.5900 mL2.5180 mL1.2590 mL
25 mg31.4750 mL6.2950 mL3.1475 mL
50 mg62.9501 mL12.5900 mL6.2950 mL
100 mg125.9002 mL25.1800 mL12.5900 mL
250 mg314.7505 mL62.9501 mL31.4750 mL

Need a different pack size or technical document?

Contact our team with the catalog number and requested quantity.

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Handling guidance

Shipping, storage and sampling

How is the lipid shipped, and how should I store it?
We generally ship the neat (undissolved) lipid compound rather than an ethanol solution. The neat lipid is stable during transport with ice packs, and shipments originate from Shanghai. Pure form: store at −20 °C for up to 1 year. In solvent: store at −80 °C for up to 6 months or at −20 °C for up to 1 month. Keep sealed and protected from light. Avoid repeated thaw cycles for best results.
Pure lipid or solution — which should I choose?
Pure lipid is generally more stable during shipping and storage, so we usually recommend the pure form. A solution in ethanol or chloroform can be supplied when required by your workflow. Tell us the intended application, solvent and target concentration so the most suitable format can be confirmed.
How should I measure a small amount of oily or viscous lipid?
Ionizable lipids are often oily liquids or viscous semisolids, so material can be lost during repeated weighing or transfer. For a small pack, dissolve the entire quantity and aliquot it volumetrically. For example, add 1 mL ethanol to 25 mg lipid to prepare a 25 mg/mL stock, then use a pipette to withdraw the required amount. For quantities above 100 mg, direct weighing with an analytical balance may be more practical. Always confirm solvent compatibility and solubility first.
Can you support formulation optimization and scale-up?
Yes. Share the RNA cargo, target tissue, administration route, formulation method and assay plan. Our team can discuss starting molar ratios, N/P ratio and scale-up requirements for research workflows.