DC65701 · Updated 27 October 2026
L-369
Instructions for Use
Before use
Check the supplied lot number, batch COA, approved SDS, quantity and retest date. Pure form: −20 °C, 1 year; In solvent: −80 °C, 6 months; −20 °C, 1 month. Sealed and protected from light.
For small quantities of viscous or oily lipid, volumetric transfer can reduce weighing losses. Confirm solvent compatibility and solubility before preparing a stock; calculated volumes do not establish solubility.
Stock-solution planning
Volume (mL) = mass (mg) × 1000 / [molecular weight × concentration (mM)].
| Mass | 10 mM | 20 mM |
|---|---|---|
| 10 mg | 1.2590 mL | 0.6295 mL |
| 25 mg | 3.1475 mL | 1.5738 mL |
| 50 mg | 6.2950 mL | 3.1475 mL |
| 100 mg | 12.5900 mL | 6.2950 mL |
Literature formulation reference
| Component | DC Chemicals product | Molecular weight | Molar ratio | Mass at 1 µmol total lipid (mg) |
|---|---|---|---|---|
| L-369 / Compound 17 | DC65701 | 794.28 | 50 | 0.397140 |
| DSPC | DC57005 | 790.15 | 10 | 0.079015 |
| Cholesterol | DCD-041 | 386.65 | 38.5 | 0.148860 |
| PEG-DMG | DC40169 | 2507 | 1.5 | 0.037605 |
Example 35 reports ionizable lipid:DSPC:cholesterol:PEG-DMG = 50:10:38.5:1.5 mol%. No unique Compound 17 N/P or lipid:siRNA mass ratio was identified. PEG-DMG mass conversion uses the catalog convention 2507.
Read the complete study conditions, biological results, tolerability and figures →