Literature-reported activity
| Endpoint | Reported result | Experimental context | Source location |
|---|---|---|---|
| TEM-116 degradation DC50 | 6.9 ± 0.13 µM | Purified TEM-116 and DegP, 6 h; SDS-PAGE quantification; mean ± SEM, n=3 | Main Fig. 2D/E and p. 4 |
| Antibiotic-adjuvant activity | Improved bacterial growth inhibition versus tazobactam at 1 mg/mL piperacillin; poorer performance at lower piperacillin concentrations | E. coli harbouring pK18-TEM-1; kinetic growth assay; piperacillin 0.1, 0.33 or 1 mg/mL | Main Fig. 3A–C, pp. 5–6; SI Table S1 |
Evidence limits
- Biochemical degradation and bacterial growth inhibition are different endpoints.
- At 100 µM for 7 h without piperacillin, OXF-232 did not show detectable TEM-1 degradation in E. coli; enhanced cellular degradation must not be assumed for this series.
- At lower piperacillin concentrations (0.1 and 0.33 mg/mL), tazobactam performed better; at 1 mg/mL piperacillin, the degrader series showed improved growth inhibition.
- The term “in vivo” in the bacterial assays refers to living bacteria, not animal infection efficacy.
- No DC stock, purity, lead time or clinical efficacy is established by the literature.
These values are reported in the cited research and depend on the experimental conditions. DC Chemicals supplies research compounds; literature results are not guaranteed product performance.
Reference
Taylor EK, Santos Barbosa P, Kadambi T, Eisele F, Wang Y, Moura ECCM, Walsh TR, Isom GL, Lanyon-Hogg T. Molecular Glue Degraders of TEM β-Lactamases by Periplasmic Protease DegP. Angewandte Chemie International Edition (2026), e3138186. DOI: 10.1002/anie.3138186.
Identity & specifications
| Product name | OXF-233 |
| Synonyms | OXF 233; OXF233; TEM DegP degrader OXF-233; 10.1002/anie.3138186 compound 2 |
| Molecular formula | C26H32N6O9S |
| Molecular weight | 604.64 |
| Structure / form | Neutral free-acid structure; no counterion assigned |
| Stereochemistry | Penam core 2S,3S,5R; L-Phe and L-Ile (2S,3S) |
| SMILES | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)c1cn(C[C@@]2(C)[C@H](C(=O)O)N3C(=O)C[C@H]3S2(=O)=O)nn1)C(=O)O |
| CAS | Not assigned |
| Supply assessment | Request synthesis assessment |
| Purity / storage / specifications | To be confirmed for the supplied batch |
Molecular formula and molecular weight were calculated from the verified structure. Literature sample purity is not a specification for a DC Chemicals batch.
Product documents
Contact us to confirm available specifications and documentation for your requested material. A batch-specific COA is available only for a released batch.
Ask about specifications and documentsTaylor EK, Santos Barbosa P, Kadambi T, Eisele F, Wang Y, Moura ECCM, Walsh TR, Isom GL, Lanyon-Hogg T. Molecular Glue Degraders of TEM β-Lactamases by Periplasmic Protease DegP. Angewandte Chemie International Edition (2026), e3138186. DOI: 10.1002/anie.3138186.