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CAT. NO. DC82209Featured

Lipid 10a-26

Pack size & price

USD

Total$600

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Ships from ShanghaiIce-pack transportPure lipid recommended

Product overview

Description & Application

Lipid 10a-26 is the catalog designation mapped to Lipid 26 in Table 10a of patent WO2021189059A2. The patent reports circular-RNA expression in mice and splenic immune-cell reporter delivery. DSPC-containing and DOPE-containing preparations are described separately, so their results and composition should not be combined without an explicit experiment match.

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Literature evidence · DC82209

Formulation & Performance

Patent evidence for circular-RNA delivery, with formulation variants and reporting limitations separated.

The product mapping uses the patent Lipid 26 structural designation and the existing catalog record. Patent results for Lipids 15, 27, 53 and 54 are not assigned to this product.

Formulation components and molecular-weight conversion

Component	DC Chemicals product	Molecular weight	Molar ratio	Mass at 1 µmol total lipid (mg)
Lipid 26 / Lipid 10a-26	DC82209	802.31	62	0.497432
DSPC (paragraph 0838)	DC57005	790.15	4	0.031606
Cholesterol	DCD-041	386.65	33	0.127594
DSPE-PEG2000	Not uniquely mapped	Not established	1	Not calculable from disclosed data

Paragraph 0838 reports a DSPC variant; paragraph 0839 separately describes a DOPE variant. Both state 16:1:4:1 by weight and 62:4:33:1 by mole. These are retained as patent-reported ratios, not independently validated equivalents. DSPE-PEG2000 MW is unassigned; fixed weighing conversion remains incomplete.

Component mass calculator

Not all inputs are assigned to a single verified study formulation; unassigned fields are blank. Enter your own values to calculate a research scenario. Molecular weights and ratios are editable. Results are calculated, not measured study data. No N/P or RNA dose is inferred.

Total lipid (µmol)

Component	Mass (mg)	Mass %
Lipid 26 / Lipid 10a-26	—	—
DSPC (paragraph 0838)	—	—
Cholesterol	—	—
DSPE-PEG2000	—	—

Keep the two patent formulation descriptions separate

Source	Helper lipid	Reported ratios	Mapping boundary
Paragraph 0838; Figs. 32-35 captions	DSPC	16:1:4:1 weight; 62:4:33:1 molar	Organ-expression figures explicitly name DSPC.
Paragraph 0839	DOPE	Same ratios printed in the patent	Describes Lipids 26 and 27. Do not replace DSPC in the figure-caption formulation silently.
Paragraph 0840	DOPE	50:10:38.5:1.5 molar	This belongs to Lipids 53 and 54, not Lipid 26.

Mouse circular-RNA expression

Endpoint	Finding	Context
Whole-body expression	Lipid 26 showed higher total flux than 22-S14 and 93-S14.	Example 38, paragraphs 0843-0844; Fig. 32A. Female mice, 0.5 mg/kg FLuc circRNA IV; reporter analysis six hours after dosing.
Organ expression	Higher overall ex vivo signal while retaining a spleen-to-liver expression relationship described as favorable by the patent.	Figs. 32B and 35; no numeric fold change estimated from the plots.
Measurement meaning	Luminescence measures reporter expression.	It is not a percentage of injected particles delivered to the spleen.

Splenic immune-cell reporter evidence

Endpoint	Finding	Source / limit
Myeloid and T cells	Higher Cre-circRNA reporter transfection than Lipid 93-S14.	Paragraphs 0861-0862 and Fig. 45; Ai9 mouse tdTomato reporter, mean ± SD, n=3.
B-cell population	Reporter-positive B cells were evaluated alongside myeloid and T-cell subsets.	Do not convert this into B-cell depletion or CAR efficacy.
Other CAR experiments	Not assigned to this catalog lipid without an explicit lipid-to-experiment match.	Platform-level CAR examples are distinct from Lipid 26-specific reporter evidence.

Unresolved characterization and safety

Item	Status
Particle size, PDI, encapsulation	Characterization tables occur in the scanned patent; target-specific values were not confidently transcribed in this review.
N/P and lipid:RNA mass ratio	Not assigned from the four-lipid weight ratio.
Tolerability	No complete Lipid 26-specific toxicology profile established from the reviewed examples.
Evidence level	Patent-reported experimental evidence; no independent clinical efficacy claim.

Original study figures

Patent figures: organ expression and immune-cell reporters — Original source figures.

References and source locations

Wesselhoeft A, Goodman B et al. Circular RNA compositions and methods. WO2021189059A2 (2021). Paragraphs 0838-0844, 0861-0862; Figures 32, 35 and 45.

CAS No.	2648693-32-5
Chemical Name	Lipid 10a-26
Synonyms	Decanoic acid, 2-hexyl-, 1,1′-[[[3-(1H -imidazol-1-yl)propyl]imino]di-6, 1-hexanediyl] ester (ACI),Lipid A26,ORNA Lipid 10a26
SMILES	O=C(OCCCCCCN(CCCN1C=NC=C1)CCCCCCOC(=O)C(CCCCCC)CCCCCCCC)C(CCCCCC)CCCCCCCC
Formula	C50H95N3O4
M.Wt	802.31
Purity	>95% by ELSD-HPLC
Storage	Pure form: −20 °C, 1 year; In solvent: −80 °C, 6 months; −20 °C, 1 month. Sealed and protected from light.
Shipping condition	Ships from Shanghai. Pure lipid is stable during ice-pack transport.
Publication	Wesselhoeft A, Goodman B et al. Circular RNA compositions and methods. WO2021189059A2 (2021). Paragraphs 0838-0844, 0861-0862; Figures 32, 35 and 45.

Laboratory planning

Solution Calculators

The product molecular weight is prefilled when available and remains editable. Confirm solvent compatibility and solubility before preparation.

No N/P or lipid:cargo mass ratio was reported; none is calculated.

Mass = concentration × volume × molecular weight

MassConcentrationVolumeMolecular weightg/mol

Enter any three values to calculate the fourth.

C₁V₁ = C₂V₂

C₁mMV₁mLC₂mMV₂mL

Enter any three values to calculate the fourth.

Preparing stock solutions

Quick preparation table

Solvent volumes update from the molecular weight above.

Mass	1 mM	5 mM	10 mM
10 mg	12.4640 mL	2.4928 mL	1.2464 mL
25 mg	31.1600 mL	6.2320 mL	3.1160 mL
50 mg	62.3201 mL	12.4640 mL	6.2320 mL
100 mg	124.6401 mL	24.9280 mL	12.4640 mL
250 mg	311.6003 mL	62.3201 mL	31.1600 mL

Need a different pack size or technical document?

Contact our team with the catalog number and requested quantity.

Handling guidance

Shipping, storage and sampling

How is the lipid shipped, and how should I store it?

We generally ship the neat (undissolved) lipid compound rather than an ethanol solution. The neat lipid is stable during transport with ice packs, and shipments originate from Shanghai. Pure form: store at −20 °C for up to 1 year. In solvent: store at −80 °C for up to 6 months or at −20 °C for up to 1 month. Keep sealed and protected from light. Avoid repeated thaw cycles for best results.

Pure lipid or solution — which should I choose?

Pure lipid is generally more stable during shipping and storage, so we usually recommend the pure form. A solution in ethanol or chloroform can be supplied when required by your workflow. Tell us the intended application, solvent and target concentration so the most suitable format can be confirmed.

How should I measure a small amount of oily or viscous lipid?

Ionizable lipids are often oily liquids or viscous semisolids, so material can be lost during repeated weighing or transfer. For a small pack, dissolve the entire quantity and aliquot it volumetrically. For example, add 1 mL ethanol to 25 mg lipid to prepare a 25 mg/mL stock, then use a pipette to withdraw the required amount. For quantities above 100 mg, direct weighing with an analytical balance may be more practical. Always confirm solvent compatibility and solubility first.

Can you support formulation optimization and scale-up?

Yes. Share the RNA cargo, target tissue, administration route, formulation method and assay plan. Our team can discuss starting molar ratios, N/P ratio and scale-up requirements for research workflows.

Lipid 10a-26

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Description & Application

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