Lipid 10a-26
Version 1.df2b8b96 · 2026-09-13
| CAS No. | Not available |
| Chemical Name | Lipid 10a-26 |
| Synonyms | Decanoic acid, 2-hexyl-, 1,1′-[[[3-(1H -imidazol-1-yl)propyl]imino]di-6, 1-hexanediyl] ester (ACI),Lipid A26,ORNA Lipid 10a26 |
| SMILES | O=C(OCCCCCCN(CCCN1C=NC=C1)CCCCCCOC(=O)C(CCCCCC)CCCCCCCC)C(CCCCCC)CCCCCCCC |
| Formula | C50H95N3O4 |
| M.Wt | 802.31 |
| Purity | ELSD-HPLC>95% |
| Storage | Original product: up to 1 year under the storage conditions stated on the vial, kept tightly sealed. Stock solutions: aliquots at -20°C, generally up to one month. |
| Shipping condition | Ships from Shanghai. Pure lipid is stable during ice-pack transport. |
| Publication | Circular RNA compositions for targeted and efficient therapeutic protein expression in immune cells for treating cancer or autoimmune disease By: Wesselhoeft, Alex; Goodman, Brian-WO2021189059 A2 2021-09-23 |
Lipid 10a-26 is an ionizable lipid developed by Orna Therapeutics for lipid nanoparticle (LNP) formulations. Lipid 10a-26 is a key ionizable lipid in the LNP-6 formulation. Through structural modification, it exhibits reduced binding to ApoE proteins and lowered liver affinity compared to traditional ionizable lipids. Instead, Lipid 10a-26 demonstrates strong splenic tropism—in non-human primate studies, it effectively delivers payloads to the spleen and immune cells in peripheral blood, such as T cells, NK cells, and macrophages, enabling the possibility of "in vivo CAR-T" therapy. Its pKa is tuned to approximately 6.0–6.5, allowing rapid protonation in the acidic endosomal environment, which promotes endosomal membrane disruption and efficient cytosolic release of circular RNA.
Specifications shown are product-page values, not batch test results.
Read Instructions for Use →