DMA4-H228
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Ionizable lipid for LNP and nucleic-acid delivery research.
A12-Iso5-2DC18 is a novel amine containing lipid can be used for mRNA delivery, activate the stimulator of interferon genes (STING) pathway, and exhibit anti-tumor immunity.
| CAS No. | Not available |
| Chemical Name | A12-Iso5-2DC18 |
| Synonyms | 1H -Imidazole-2-carboxylic acid, 1-[3-(dimethylamino)propyl]-5,5-di- (8Z )-8-heptadecen-1-yl-2,5-dihydro-, ethyl ester (ACI);A12Iso52DC18, A12 Iso5 2DC18 |
| SMILES | C(CCCCCC/C=C\CCCCCCCC)C1(CCCCCCC/C=C\CCCCCCCC)N(CCCN(C)C)C(C(OCC)=O)N=C1 |
| Formula | C45H85N3O2 |
| M.Wt | 700.18 |
| Purity | ELSD-HPLC>95% |
| Storage | Pure form: −20 °C, 1 year; In solvent: −80 °C, 6 months; −20 °C, 1 month. Sealed and protected from light. |
| Shipping condition | Ships from Shanghai. Pure lipid is stable during ice-pack transport. |
| Publication | Synthesis of ionizable lipidoids for pharmaceutical use By: Miao, Lei; Li, Linxian; Anderson, Daniel Griffith; Huang, Yuxuan World Intellectual Property Organization, WO2020047399 A1 2020-03-05. |
The product molecular weight is prefilled when available and remains editable. Confirm solvent compatibility and solubility before preparation.
Solvent volumes update from the molecular weight above.
| Mass | 1 mM | 5 mM | 10 mM |
|---|---|---|---|
| 10 mg | 14.2820 mL | 2.8564 mL | 1.4282 mL |
| 25 mg | 35.7051 mL | 7.1410 mL | 3.5705 mL |
| 50 mg | 71.4102 mL | 14.2820 mL | 7.1410 mL |
| 100 mg | 142.8204 mL | 28.5641 mL | 14.2820 mL |
| 250 mg | 357.0510 mL | 71.4102 mL | 35.7051 mL |
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