Literature-reported formulation composition
Component: A12-Iso5-2DC18 | mol%: 35 | Role: Ionizable lipid
sales@dcchemicals.com
A12-Iso5-2DC18
Literature records
Search the tables and observations reproduced from the product literature guide. Rows may represent measurements, recipes or experimental context; they are not all independent experiments.
Literature-reported formulation composition
Component: DOPE | mol%: 16 | Role: Helper phospholipid
Literature-reported formulation composition
Component: Cholesterol | mol%: 37.5 | Role: Sterol
Literature-reported formulation composition
Component: C14-PEG | mol%: 2.5 | Role: PEG lipid
Literature-reported formulation composition
Component: Reported total | mol%: 91 | Role: Source values retained
Reported observation
Literature-reported mRNA delivery A12 and A2 induced similar levels of protein expression in local tissue and draining lymph nodes and transfected macrophage/monocyte and dendritic-cell populations. mLuc or Cre mRNA LNPs in mice · A2 LNPs WO2020047399A1 [00266], Figures 3B-3G and 12.
Reported observation
Literature-reported Antigen-specific immunity A12 mOVA LNPs produced lower CTL and IFN-gamma responses than A2 mOVA LNPs in the cited comparison. mOVA vaccination · A2 mOVA LNPs WO2020047399A1 [00267], Figures 3H and 13.
Reported observation
Literature-reported Anti-tumor efficacy A12 mOVA LNPs showed almost no anti-tumor efficacy in the B16F10-OVA model under the reported conditions. Two-dose mOVA vaccination, once every five days · A2 mOVA LNPs WO2020047399A1 [00267]-[00268], Figure 3I.
Reported observation
Literature-reported Relative delivery Both A2 and A12 were identified as high-performing 2DC18/ethyl-isocyanoacetate lipidoids and were approximately two-fold higher than Dlin-KC3-DMA in the cited comparison. In-vitro and in-vivo screening · Dlin-KC3-DMA WO2020047399A1 [00263].
Reported observation
Structure-function context The patent links reduced tail saturation, the 2DC18 ketone and ethyl isocyanoacetate substructure with improved delivery across the broader lipidoid library; these are library-level observations and not A12-only causal tests. · WO2020047399A1 [00262]-[00263].