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Ionizable lipids / 503O8,12
503O8,12 chemical structure
Product imageResearch use only
CAT. NO. DC60808Featured

503O8,12

Ionizable lipid for LNP and nucleic-acid delivery research.

Pack size & price

USD
TotalUS$650
We match the best price and quality on market.
Ships from ShanghaiIce-pack transportPure lipid recommended
Product overview

Description & Application

503O8,12​​ is an ionizable lipidoid synthesized via Michael addition, combining a hydrophilic amine headgroup ("503" series) with two hydrophobic branched acrylate tails (C8 and C12 chains, likely with unsaturated bonds). Its design emphasizes organ-specific delivery, exhibiting ​​spleen-tropic targeting​​ in vivo.

CAS No.Not available
Chemical Name503O8,12
Synonyms503,O8,12, 503O,8,12
SMILESCCCCCCCCCCC(CCCCCCCC)COC(=O)CCN(CCC(=O)OCC(CCCCCCCC)CCCCCCCCCC)CCN(C)CCCN(C)CCN(CCC(=O)OCC(CCCCCCCC)CCCCCCCCCC)CCC(=O)OCC(CCCCCCCC)CCCCCCCCCC
FormulaC101H200N4O8
M.Wt1,598.69
PurityELSD-HPLC>95%
StoragePure form: −20 °C, 1 year; In solvent: −80 °C, 6 months; −20 °C, 1 month. Sealed and protected from light.
Shipping conditionShips from Shanghai. Pure lipid is stable during ice-pack transport.
PublicationBranched-Tail Lipid Nanoparticles for Intravenous mRNA delivery to Lung Immune, Endothelial, and Alveolar Cells in Mice- Mariah L. Arral, and Kathryn A. Whitehead-Science Advane Adv Healthc Mater . 2024 Sep;13(22):e2400225
Laboratory planning

Solution Calculators

The product molecular weight is prefilled when available and remains editable. Confirm solvent compatibility and solubility before preparation.

Mass = concentration × volume × molecular weight
Enter any three values to calculate the fourth.
C₁V₁ = C₂V₂
Enter any three values to calculate the fourth.
Preparing stock solutions

Quick preparation table

Solvent volumes update from the molecular weight above.

Mass1 mM5 mM10 mM
10 mg6.2551 mL1.2510 mL625.51 μL
25 mg15.6378 mL3.1276 mL1.5638 mL
50 mg31.2756 mL6.2551 mL3.1276 mL
100 mg62.5512 mL12.5102 mL6.2551 mL
250 mg156.3780 mL31.2756 mL15.6378 mL

Need a different pack size or technical document?

Contact our team with the catalog number and requested quantity.

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Handling guidance

Shipping, storage and sampling

How is the lipid shipped, and how should I store it?
We generally ship the neat (undissolved) lipid compound rather than an ethanol solution. The neat lipid is stable during transport with ice packs, and shipments originate from Shanghai. Pure form: store at −20 °C for up to 1 year. In solvent: store at −80 °C for up to 6 months or at −20 °C for up to 1 month. Keep sealed and protected from light. Avoid repeated thaw cycles for best results.
Pure lipid or solution — which should I choose?
Pure lipid is generally more stable during shipping and storage, so we usually recommend the pure form. A solution in ethanol or chloroform can be supplied when required by your workflow. Tell us the intended application, solvent and target concentration so the most suitable format can be confirmed.
How should I measure a small amount of oily or viscous lipid?
Ionizable lipids are often oily liquids or viscous semisolids, so material can be lost during repeated weighing or transfer. For a small pack, dissolve the entire quantity and aliquot it volumetrically. For example, add 1 mL ethanol to 25 mg lipid to prepare a 25 mg/mL stock, then use a pipette to withdraw the required amount. For quantities above 100 mg, direct weighing with an analytical balance may be more practical. Always confirm solvent compatibility and solubility first.
Can you support formulation optimization and scale-up?
Yes. Share the RNA cargo, target tissue, administration route, formulation method and assay plan. Our team can discuss starting molar ratios, N/P ratio and scale-up requirements for research workflows.