C18 NC-TNP
Recommended because it shares a closely related research category or delivery context. Formulation and performance are product- and study-specific.
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Ionizable lipid for LNP and nucleic-acid delivery research.
503O8,12 is an ionizable lipidoid synthesized via Michael addition, combining a hydrophilic amine headgroup ("503" series) with two hydrophobic branched acrylate tails (C8 and C12 chains, likely with unsaturated bonds). Its design emphasizes organ-specific delivery, exhibiting spleen-tropic targeting in vivo.
| CAS No. | Not available |
| Chemical Name | 503O8,12 |
| Synonyms | 503,O8,12, 503O,8,12 |
| SMILES | CCCCCCCCCCC(CCCCCCCC)COC(=O)CCN(CCC(=O)OCC(CCCCCCCC)CCCCCCCCCC)CCN(C)CCCN(C)CCN(CCC(=O)OCC(CCCCCCCC)CCCCCCCCCC)CCC(=O)OCC(CCCCCCCC)CCCCCCCCCC |
| Formula | C101H200N4O8 |
| M.Wt | 1,598.69 |
| Purity | ELSD-HPLC>95% |
| Storage | Pure form: −20 °C, 1 year; In solvent: −80 °C, 6 months; −20 °C, 1 month. Sealed and protected from light. |
| Shipping condition | Ships from Shanghai. Pure lipid is stable during ice-pack transport. |
| Publication | Branched-Tail Lipid Nanoparticles for Intravenous mRNA delivery to Lung Immune, Endothelial, and Alveolar Cells in Mice- Mariah L. Arral, and Kathryn A. Whitehead-Science Advane Adv Healthc Mater . 2024 Sep;13(22):e2400225 |
The product molecular weight is prefilled when available and remains editable. Confirm solvent compatibility and solubility before preparation.
Solvent volumes update from the molecular weight above.
| Mass | 1 mM | 5 mM | 10 mM |
|---|---|---|---|
| 10 mg | 6.2551 mL | 1.2510 mL | 625.51 μL |
| 25 mg | 15.6378 mL | 3.1276 mL | 1.5638 mL |
| 50 mg | 31.2756 mL | 6.2551 mL | 3.1276 mL |
| 100 mg | 62.5512 mL | 12.5102 mL | 6.2551 mL |
| 250 mg | 156.3780 mL | 31.2756 mL | 15.6378 mL |
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