For research use only. We do not sell to patients.
Ionizable lipids / lipid 14
lipid 14 chemical structure
Product imageResearch use only
CAT. NO. DC82125Featured

lipid 14

Research highlights
Lipid 14/cholesterol/DSPC/PEG-DMG = 40:47.5:10.5:2 mol%.The reported particles averaged 61.5 nm with PDI 0.132 and all mRNA-LNP formulations had >92% encapsulation efficiency.Mice received 5 microgram mRNA-LNP doses by intramuscular injection with repeated boosts in the uploaded preprint; the final paper also reports a single-dose F1 vaccine study.SP-caf1-hFc and deltaSP-caf1 mRNA-LNP vaccination conferred full protection in the lethal Y. pestis Kim53 challenge model under the reported preprint protocol.

Pack size & price

USD
Total$800
We match the best price and quality on market.
Ships from ShanghaiIce-pack transportPure lipid recommended
Product overview

Description & Application

LIPID 14 is a novel ionizable lipid used for mRNA delivery.In 2021, Elia et al. used lipid 2 LNPs and lipid 14 LNPs to deliver mRNA encoding SARSCoV-2 human Fc-conjugated receptor binding domain (RBDhFc mRNA). While both lipid 274 LNP RBD-hFc mRNA and lipid 14 LNP RBD-hFc mRNA induced equal cellular and humoral responses in mice at an mRNA dose of 5 μg, only lipid 14 LNP RBD-hFc mRNA exhibited strong immunogenicity following intradermal administration. Both intradermal administration and intramuscular administration of lipid 14 LNPs could activate antigen presenting cells (APCs), thus inducing cellular responses.

CAS No.2430034-05-0
Chemical Namelipid 14
Synonymslipid-14， lipid14
SMILESO=C(OCCN(CCCCCCCCOC(C(CCCCCC)CCCCCCCC)=O)CCCCCCCCOC(C(CCCCCC)CCCCCCCC)=O)CCCN(C)C
FormulaC56H110N2O6
M.Wt907.48
Purity>95% by ELSD-HPLC
StoragePure form: −20 °C, 1 year; In solvent: −80 °C, 6 months; −20 °C, 1 month. Sealed and protected from light.
Shipping conditionShips from Shanghai. Pure lipid is stable during ice-pack transport.
PublicationKon E, Levy Y, Elia U, et al. An Effective mRNA-LNP Vaccine Against the Lethal Plague Bacterium. bioRxiv. 2022. Kon E, Levy Y, Elia U, et al. A single-dose F1-based mRNA-LNP vaccine provides protection against the lethal plague bacterium. Science Advances. 2023;9(10):eadg1036.
Laboratory planning

Solution Calculators

The product molecular weight is prefilled when available and remains editable. Confirm solvent compatibility and solubility before preparation.

No N/P or lipid:RNA mass ratio was reported; no conversion is made.

Mass = concentration × volume × molecular weight
Enter any three values to calculate the fourth.
C₁V₁ = C₂V₂
Enter any three values to calculate the fourth.
Preparing stock solutions

Quick preparation table

Solvent volumes update from the molecular weight above.

Mass1 mM5 mM10 mM
10 mg11.0195 mL2.2039 mL1.1020 mL
25 mg27.5488 mL5.5098 mL2.7549 mL
50 mg55.0976 mL11.0195 mL5.5098 mL
100 mg110.1953 mL22.0391 mL11.0195 mL
250 mg275.4882 mL55.0976 mL27.5488 mL

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Handling guidance

Shipping, storage and sampling

How is the lipid shipped, and how should I store it?
We generally ship the neat (undissolved) lipid compound rather than an ethanol solution. The neat lipid is stable during transport with ice packs, and shipments originate from Shanghai. Pure form: store at −20 °C for up to 1 year. In solvent: store at −80 °C for up to 6 months or at −20 °C for up to 1 month. Keep sealed and protected from light. Avoid repeated thaw cycles for best results.
Pure lipid or solution — which should I choose?
Pure lipid is generally more stable during shipping and storage, so we usually recommend the pure form. A solution in ethanol or chloroform can be supplied when required by your workflow. Tell us the intended application, solvent and target concentration so the most suitable format can be confirmed.
How should I measure a small amount of oily or viscous lipid?
Ionizable lipids are often oily liquids or viscous semisolids, so material can be lost during repeated weighing or transfer. For a small pack, dissolve the entire quantity and aliquot it volumetrically. For example, add 1 mL ethanol to 25 mg lipid to prepare a 25 mg/mL stock, then use a pipette to withdraw the required amount. For quantities above 100 mg, direct weighing with an analytical balance may be more practical. Always confirm solvent compatibility and solubility first.
Can you support formulation optimization and scale-up?
Yes. Share the RNA cargo, target tissue, administration route, formulation method and assay plan. Our team can discuss starting molar ratios, N/P ratio and scale-up requirements for research workflows.