PRODUCT DATASHEET · DC82125
lipid 14
Version 1.88a06854 · 2026-09-13
| CAS No. | Not available |
| Chemical Name | lipid 14 |
| Synonyms | lipid-14， lipid14 |
| SMILES | O=C(OCCN(CCCCCCCCOC(C(CCCCCC)CCCCCCCC)=O)CCCCCCCCOC(C(CCCCCC)CCCCCCCC)=O)CCCN(C)C |
| Formula | C56H110N2O6 |
| M.Wt | 907.48 |
| Purity | >95% |
| Storage | Original product: up to 1 year under the storage conditions stated on the vial, kept tightly sealed. Stock solutions: aliquots at -20°C, generally up to one month. |
| Shipping condition | Ships from Shanghai. Pure lipid is stable during ice-pack transport. |
| Publication | 1 An Effective mRNA-LNP Vaccine Against the Lethal Plague Bacterium Edo Kon,Dan Peer, Ofer Cohen-doi: biorxiv, https://doi.org/10.1101/2022.08.07.503096 ||2 Elia, U.; Ramishetti, S.; Rosenfeld, R.; Dammes, N.; Bar-Haim, E.; Naidu, G. S.; Makdasi, E.; Yahalom-Ronen, Y.; Tamir, H.; Paran, N.;et al. Design of SARS-CoV-2 hFc-Conjugated Receptor-Binding Domain mRNA Vaccine Delivered via Lipid Nanoparticles. ACS Nano 2021 ||3 : A single-dose F1-based mRNA-LNP vaccine provides protection against the lethal plague bacterium E Kon, Y Levy, U Elia, H Cohen, I Hazan-Halevy… - Science Advances, 2023 |
LIPID 14 is a novel ionizable lipid used for mRNA delivery.In 2021, Elia et al. used lipid 2 LNPs and lipid 14 LNPs to deliver mRNA encoding SARSCoV-2 human Fc-conjugated receptor binding domain (RBDhFc mRNA). While both lipid 274 LNP RBD-hFc mRNA and lipid 14 LNP RBD-hFc mRNA induced equal cellular and humoral responses in mice at an mRNA dose of 5 μg, only lipid 14 LNP RBD-hFc mRNA exhibited strong immunogenicity following intradermal administration. Both intradermal administration and intramuscular administration of lipid 14 LNPs could activate antigen presenting cells (APCs), thus inducing cellular responses.
Specifications shown are product-page values, not batch test results.
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