DLin-MC3-DMA
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Ionizable lipid for LNP and nucleic-acid delivery research.
YSK 05 is a pH-sensitive cationic lipid. YSK 05 improves the intracellular trafficking of non-viral vectors. YSK 05-MEND shows significantly good gene silencing activity and hemolytic activity. YSK 05 overcomes the suppression of endosomal escape by PEGylation. YSK 05 effectively enhances siRNA delivery both in vitro and in vivo.
| CAS No. | Not available |
| Chemical Name | YSK 05 |
| Synonyms | Piperidine, 1-methyl-4,4-bis[(9Z,12Z)-9,12-octadecadien-1-yloxy]-;YSK-05,YSK05 |
| SMILES | N1(C)CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)(OCCCCCCCC/C=C\C/C=C\CCCCC)CC1 |
| Formula | C42H77NO2 |
| M.Wt | 628.07 |
| Purity | ELSD-HPLC>95% |
| Storage | Pure form: −20 °C, 1 year; In solvent: −80 °C, 6 months; −20 °C, 1 month. Sealed and protected from light. |
| Shipping condition | Ships from Shanghai. Pure lipid is stable during ice-pack transport. |
| Publication | [1]. Sato Y, et al. A pH-sensitive cationic lipid facilitates the delivery of liposomal siRNA and gene silencing activity in vitro and in vivo. J Control Release. 2012 Nov 10;163(3):267-76. |
The product molecular weight is prefilled when available and remains editable. Confirm solvent compatibility and solubility before preparation.
Solvent volumes update from the molecular weight above.
| Mass | 1 mM | 5 mM | 10 mM |
|---|---|---|---|
| 10 mg | 15.9218 mL | 3.1844 mL | 1.5922 mL |
| 25 mg | 39.8045 mL | 7.9609 mL | 3.9804 mL |
| 50 mg | 79.6090 mL | 15.9218 mL | 7.9609 mL |
| 100 mg | 159.2179 mL | 31.8436 mL | 15.9218 mL |
| 250 mg | 398.0448 mL | 79.6090 mL | 39.8045 mL |
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