For research use only. We do not sell to patients.
Ionizable lipids / XH-07
XH-07 chemical structure
Product imageResearch use only
CAT. NO. DC67983Featured

XH-07

Pack size & price

USD
Total$950
We match the best price and quality on market.
Ships from ShanghaiIce-pack transportPure lipid recommended
Product overview

Description & Application

XH-07 is an ionizable cationic lipid reported as the lipid carrier in JCXH-211, an experimental IL-12 RNA lipid nanoparticle formulation studied in preclinical cancer models. The published work describes cellular IL-12 expression, antitumor responses and exploratory tolerability observations for the complete formulation. XH-07 is supplied as a research reagent; these findings do not establish the activity or safety of the isolated lipid, or equivalent results with other RNA cargoes.

CAS No.Not available
Chemical NameXH-07
SynonymsXH07;XH 07
SMILESCCCCCCCCCOC(=O)CCCCCCCOC1=CC=C(OCCCCCCCC(=O)OC(CCCCCCCC)CCCCCCCC)C=C1COC(=O)CCCN(C)C
FormulaC55H99O8N
M.Wt902.40
Purity>98%
StoragePure form: −20 °C, 1 year; In solvent: −80 °C, 6 months; −20 °C, 1 month. Sealed and protected from light.
Shipping conditionShips from Shanghai. Pure lipid is stable during ice-pack transport.
PublicationWang et al., Scientific Reports 14, 7366 (2024)

Formulation & Performance

Published evidence for XH-07 as the carrier lipid in JCXH-211.

The biological results belong to the complete RNA–LNP formulation, not to isolated XH-07.

Read the full literature analysis →

Reported attributeResultInterpretation / source
Mean particle diameterApproximately 80 nmComplete formulated particles, not a specification of neat XH-07. Main article, Methods; Supplementary Fig. 1.
Polydispersity index0.07–0.16Reported formulation characterization range; not a guaranteed lot-release range for the supplied lipid. Main article, Methods.
RNA encapsulationAbove 85%Reported for the complete formulation. Main article, Methods.
Zeta potentialDistribution shown in Supplementary Fig. 1BThe previous catalog value is not used as a universal or independently verified specification.

Biological evidence at a glance

  • Cellular expression and tissue distribution are assessed as separate endpoints.
  • B16F10 and EMT6 studies report tumor responses, with combination effects dependent on the experimental context.
  • Primate observations are exploratory (two animals), not a comprehensive safety demonstration.

Wang Z, Chen Y, Wu H, et al. Intravenous administration of IL-12 encoding self-replicating RNA-lipid nanoparticle complex leads to safe and effective antitumor responses. Scientific Reports 14, 7366 (2024). doi:10.1038/s41598-024-57997-w. Main article and accompanying Supplementary Material reviewed.

LITFormulation & PerformanceCellular and animal evidence with referencesRead online →
Laboratory planning

Solution Calculators

The product molecular weight is prefilled when available and remains editable. Confirm solvent compatibility and solubility before preparation.

Mass = concentration × volume × molecular weight
Enter any three values to calculate the fourth.
C₁V₁ = C₂V₂
Enter any three values to calculate the fourth.
Preparing stock solutions

Quick preparation table

Solvent volumes update from the molecular weight above.

Mass1 mM5 mM10 mM
10 mg11.0816 mL2.2163 mL1.1082 mL
25 mg27.7039 mL5.5408 mL2.7704 mL
50 mg55.4078 mL11.0816 mL5.5408 mL
100 mg110.8156 mL22.1631 mL11.0816 mL
250 mg277.0390 mL55.4078 mL27.7039 mL

Need a different pack size or technical document?

Contact our team with the catalog number and requested quantity.

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Handling guidance

Shipping, storage and sampling

How is the lipid shipped, and how should I store it?
We generally ship the neat (undissolved) lipid compound rather than an ethanol solution. The neat lipid is stable during transport with ice packs, and shipments originate from Shanghai. Pure form: store at −20 °C for up to 1 year. In solvent: store at −80 °C for up to 6 months or at −20 °C for up to 1 month. Keep sealed and protected from light. Avoid repeated thaw cycles for best results.
Pure lipid or solution — which should I choose?
Pure lipid is generally more stable during shipping and storage, so we usually recommend the pure form. A solution in ethanol or chloroform can be supplied when required by your workflow. Tell us the intended application, solvent and target concentration so the most suitable format can be confirmed.
How should I measure a small amount of oily or viscous lipid?
Ionizable lipids are often oily liquids or viscous semisolids, so material can be lost during repeated weighing or transfer. For a small pack, dissolve the entire quantity and aliquot it volumetrically. For example, add 1 mL ethanol to 25 mg lipid to prepare a 25 mg/mL stock, then use a pipette to withdraw the required amount. For quantities above 100 mg, direct weighing with an analytical balance may be more practical. Always confirm solvent compatibility and solubility first.
Can you support formulation optimization and scale-up?
Yes. Share the RNA cargo, target tissue, administration route, formulation method and assay plan. Our team can discuss starting molar ratios, N/P ratio and scale-up requirements for research workflows.