E10i-494
Recommended because it shares a closely related research category or delivery context. Formulation and performance are product- and study-specific.
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Ionizable lipid for LNP and nucleic-acid delivery research.
BCP-NC2-C12 is an ionizable cationic lipid designed for mRNA delivery, forming LNPs that predominantly localize to hepatic and splenic tissues in vivo. When formulated with CRISPR-Cas9 components (Cas9 mRNA and Pcsk9-targeting sgRNA), these LNPs effectively generate gene-editing indels and significantly lower circulating PCSK9 levels in murine models.
| CAS No. | Not available |
| Chemical Name | BCP-NC2-C12 |
| Synonyms | N1,N3-bis(2-(didodecylamino)ethyl)bicyclo[1.1.1]pentane-1,3-dicarboxamide,BCPNC2C12, BCP NC2 C12 |
| SMILES | O=C(NCCN(CCCCCCCCCCCC)CCCCCCCCCCCC)C1(C2)CC2(C(NCCN(CCCCCCCCCCCC)CCCCCCCCCCCC)=O)C1 |
| Formula | C59H116N4O2 |
| M.Wt | 913.6 |
| Purity | >98% |
| Storage | Pure form: −20 °C, 1 year; In solvent: −80 °C, 6 months; −20 °C, 1 month. Sealed and protected from light. |
| Shipping condition | Ships from Shanghai. Pure lipid is stable during ice-pack transport. |
| Publication | Not available |
The product molecular weight is prefilled when available and remains editable. Confirm solvent compatibility and solubility before preparation.
Solvent volumes update from the molecular weight above.
| Mass | 1 mM | 5 mM | 10 mM |
|---|---|---|---|
| 10 mg | 10.9457 mL | 2.1891 mL | 1.0946 mL |
| 25 mg | 27.3643 mL | 5.4729 mL | 2.7364 mL |
| 50 mg | 54.7285 mL | 10.9457 mL | 5.4729 mL |
| 100 mg | 109.4571 mL | 21.8914 mL | 10.9457 mL |
| 250 mg | 273.6427 mL | 54.7285 mL | 27.3643 mL |
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