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BCP-NC2-C12

Version 1.4d93d6cb · 2026-09-13

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CAS No.Not available
Chemical NameBCP-NC2-C12
SynonymsN1,N3-bis(2-(didodecylamino)ethyl)bicyclo[1.1.1]pentane-1,3-dicarboxamide,BCPNC2C12, BCP NC2 C12
SMILESO=C(NCCN(CCCCCCCCCCCC)CCCCCCCCCCCC)C1(C2)CC2(C(NCCN(CCCCCCCCCCCC)CCCCCCCCCCCC)=O)C1
FormulaC59H116N4O2
M.Wt913.6
Purity>98%
StorageOriginal product: up to 1 year under the storage conditions stated on the vial, kept tightly sealed. Stock solutions: aliquots at -20°C, generally up to one month.
Shipping conditionShips from Shanghai. Pure lipid is stable during ice-pack transport.
PublicationNot available

BCP-NC2-C12 is an ionizable cationic lipid designed for mRNA delivery, forming LNPs that predominantly localize to hepatic and splenic tissues in vivo. When formulated with CRISPR-Cas9 components (Cas9 mRNA and Pcsk9-targeting sgRNA), these LNPs effectively generate gene-editing indels and significantly lower circulating PCSK9 levels in murine models.

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