DLin-MC3-DMA
Recommended because it shares a closely related research category or delivery context. Formulation and performance are product- and study-specific.
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Ionizable lipid for LNP and nucleic-acid delivery research.
O12-D3-I3 is an imidazole-based lipid for siRNA delivery. O12-D3-I3-LNPs encapsulating FVII siRNA (FVII@O-LNP) elicites greater gene silencing than those with the DLin-MC3-DMA (MC3) due to its stronger endosomal escape.
| CAS No. | Not available |
| Chemical Name | O12-D3-I3 |
| Synonyms | O12D3I3, O12 D3 I3 |
| SMILES | O=C(NCCCN(CCC(OCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCC)=O)C(N)CC1=CNC=N1 |
| Formula | C39H73N5O5 |
| M.Wt | 692.0 |
| Purity | >98% |
| Storage | Pure form: −20 °C, 1 year; In solvent: −80 °C, 6 months; −20 °C, 1 month. Sealed and protected from light. |
| Shipping condition | Ships from Shanghai. Pure lipid is stable during ice-pack transport. |
| Publication | Not available |
The product molecular weight is prefilled when available and remains editable. Confirm solvent compatibility and solubility before preparation.
Solvent volumes update from the molecular weight above.
| Mass | 1 mM | 5 mM | 10 mM |
|---|---|---|---|
| 10 mg | 14.4509 mL | 2.8902 mL | 1.4451 mL |
| 25 mg | 36.1272 mL | 7.2254 mL | 3.6127 mL |
| 50 mg | 72.2543 mL | 14.4509 mL | 7.2254 mL |
| 100 mg | 144.5087 mL | 28.9017 mL | 14.4509 mL |
| 250 mg | 361.2717 mL | 72.2543 mL | 36.1272 mL |
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