For research use only. We do not sell to patients.
Ionizable lipids / IR-117-17
IR-117-17 chemical structure
Product imageResearch use only
CAT. NO. DC60506

IR-117-17

Ionizable lipid for LNP and nucleic-acid delivery research.

Pack size & price

USD
TotalUS$650
We match the best price and quality on market.
Ships from ShanghaiIce-pack transportPure lipid recommended
Product overview

Description & Application

IR-117-17 (A10-LIN) is an ionizable and biodegradable lipid specifically designed for nebulized mRNA delivery. When formulated into lipid nanoparticles (LNPs), IR-117-17 demonstrates remarkable efficacy, achieving a 300-fold enhancement in lung mRNA delivery compared to the best-performing LNP previously reported. Additionally, it shows a two-fold improvement over the leading PBAE-based delivery system, with up to a 45-fold increase in mRNA delivery efficiency to the large airways.

CAS No.Not available
Chemical NameIR-117-17
SynonymsA10-LIN;IR11717 IR 117 17
SMILESCCCCC/C=C\C/C=C\CCCCCCCC(OCCCCCC(C(CCCCOC(CCCCCCC/C=C\C/C=C\CCCCC)=O)CNCCCN(CCCC)CCCC)O)=O
FormulaC59H110N2O5
M.Wt927.52
Purity98%
StoragePure form: −20 °C, 1 year; In solvent: −80 °C, 6 months; −20 °C, 1 month. Sealed and protected from light.
Shipping conditionShips from Shanghai. Pure lipid is stable during ice-pack transport.
PublicationNot available
Laboratory planning

Solution Calculators

The product molecular weight is prefilled when available and remains editable. Confirm solvent compatibility and solubility before preparation.

Mass = concentration × volume × molecular weight
Enter any three values to calculate the fourth.
C₁V₁ = C₂V₂
Enter any three values to calculate the fourth.
Preparing stock solutions

Quick preparation table

Solvent volumes update from the molecular weight above.

Mass1 mM5 mM10 mM
10 mg10.7814 mL2.1563 mL1.0781 mL
25 mg26.9536 mL5.3907 mL2.6954 mL
50 mg53.9072 mL10.7814 mL5.3907 mL
100 mg107.8144 mL21.5629 mL10.7814 mL
250 mg269.5360 mL53.9072 mL26.9536 mL

Need a different pack size or technical document?

Contact our team with the catalog number and requested quantity.

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Handling guidance

Shipping, storage and sampling

How is the lipid shipped, and how should I store it?
We generally ship the neat (undissolved) lipid compound rather than an ethanol solution. The neat lipid is stable during transport with ice packs, and shipments originate from Shanghai. Pure form: store at −20 °C for up to 1 year. In solvent: store at −80 °C for up to 6 months or at −20 °C for up to 1 month. Keep sealed and protected from light. Avoid repeated thaw cycles for best results.
Pure lipid or solution — which should I choose?
Pure lipid is generally more stable during shipping and storage, so we usually recommend the pure form. A solution in ethanol or chloroform can be supplied when required by your workflow. Tell us the intended application, solvent and target concentration so the most suitable format can be confirmed.
How should I measure a small amount of oily or viscous lipid?
Ionizable lipids are often oily liquids or viscous semisolids, so material can be lost during repeated weighing or transfer. For a small pack, dissolve the entire quantity and aliquot it volumetrically. For example, add 1 mL ethanol to 25 mg lipid to prepare a 25 mg/mL stock, then use a pipette to withdraw the required amount. For quantities above 100 mg, direct weighing with an analytical balance may be more practical. Always confirm solvent compatibility and solubility first.
Can you support formulation optimization and scale-up?
Yes. Share the RNA cargo, target tissue, administration route, formulation method and assay plan. Our team can discuss starting molar ratios, N/P ratio and scale-up requirements for research workflows.