5A2-SC8
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Ionizable lipid for LNP and nucleic-acid delivery research.
TNT-b10 is a novel Lipid-like compound suitable for delivery of siRNA and mRNA both in vitro and in vivo TNT-b10 LLNs was more than 10-fold more potent than TNT-a10 LLNs formulated under the same condition.
| CAS No. | Not available |
| Chemical Name | TNT-b10 |
| Synonyms | TNTb10,TNT b10 |
| SMILES | CCCCCCCCCCC(O)CN(C)CCN1C(=O)N(CCN(C)CC(O)CCCCCCCCCC)C(=O)N(CCN(CC(O)CCCCCCCCCC)C)C1=O |
| Formula | C48H96N6O6 |
| M.Wt | 853.3 |
| Purity | ELSD-HPLC>95% |
| Storage | Pure form: −20 °C, 1 year; In solvent: −80 °C, 6 months; −20 °C, 1 month. Sealed and protected from light. |
| Shipping condition | Ships from Shanghai. Pure lipid is stable during ice-pack transport. |
| Publication | Effects of local structural transformation of lipid-like compounds on delivery of messenger RNA-Sci Rep . 2016 Feb 26;6:22137. doi: 10.1038/srep22137.Bin Li 1, Xiao Luo 1, Binbin Deng 2, JoLynn B Giancola 3, David W McComb 2, Thomas D Schmittgen 4, Yizhou Dong 1 |
The product molecular weight is prefilled when available and remains editable. Confirm solvent compatibility and solubility before preparation.
Solvent volumes update from the molecular weight above.
| Mass | 1 mM | 5 mM | 10 mM |
|---|---|---|---|
| 10 mg | 11.7192 mL | 2.3438 mL | 1.1719 mL |
| 25 mg | 29.2980 mL | 5.8596 mL | 2.9298 mL |
| 50 mg | 58.5960 mL | 11.7192 mL | 5.8596 mL |
| 100 mg | 117.1921 mL | 23.4384 mL | 11.7192 mL |
| 250 mg | 292.9802 mL | 58.5960 mL | 29.2980 mL |
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