DMA4-H228
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Ionizable lipid for LNP and nucleic-acid delivery research.
93-O17O is a chalcogen-containing ionizable cationic lipidoid. It has been used in the generation of lipid nanoparticles (LNPs). LNPs containing 93-O17O localize to the spleen after intravenous injection into mice.LNPs containing 93-O17O have been used for the delivery of Cre recombinase and ribonucleoproteins for genome editing in mice and for the intratumoral delivery of cGAMP to enhance cross-presentation of tumor antigens.
| CAS No. | Not available |
| Chemical Name | 93-O17O |
| Synonyms | bis(2-(tetradecyloxy)ethyl) 3,3'-((3-(1H-imidazol-1-yl)propyl)azanediyl)dipropionate;93O17O, 93 O17O |
| SMILES | O=C(OCCOCCCCCCCCCCCCCC)CCN(CCCN1C=NC=C1)CCC(OCCOCCCCCCCCCCCCCC)=O |
| Formula | C44H83N3O6 |
| M.Wt | 750.2 |
| Purity | ELSD-HPLC>95% |
| Storage | Pure form: −20 °C, 1 year; In solvent: −80 °C, 6 months; −20 °C, 1 month. Sealed and protected from light. |
| Shipping condition | Ships from Shanghai. Pure lipid is stable during ice-pack transport. |
| Publication | 1. Zhao, X., Chen, J., Qiu, M., et al. Imidazole-based synthetic lipidoids for in vivo mrna delivery into primary T lymphocytes. Angew. Chem. Int. Ed. Engl. 59(45), 20083-20089 (2020). 2. Chen, J., Qiu, M., Ye, Z., et al. In situ cancer vaccination using lipidoid nanoparticles. Sci. Adv. 7(19), eabf1244 (2021). 3. Li, Y., Yang, T., Yu, Y., et al. Combinatorial library of chalcogen-containing lipidoids for intracellular delivery of genome-editing proteins. Biomaterials 178, 652-662 (2018). |
The product molecular weight is prefilled when available and remains editable. Confirm solvent compatibility and solubility before preparation.
Solvent volumes update from the molecular weight above.
| Mass | 1 mM | 5 mM | 10 mM |
|---|---|---|---|
| 10 mg | 13.3298 mL | 2.6660 mL | 1.3330 mL |
| 25 mg | 33.3244 mL | 6.6649 mL | 3.3324 mL |
| 50 mg | 66.6489 mL | 13.3298 mL | 6.6649 mL |
| 100 mg | 133.2978 mL | 26.6596 mL | 13.3298 mL |
| 250 mg | 333.2445 mL | 66.6489 mL | 33.3244 mL |
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