Product imageResearch use only

CAT. NO. DC67567Featured

ARV-T1

Pack size & price

USD

Add the cited formulation componentsSelected ARV-T1 pack + every supporting component at 100 mg each+US$450 / set

Supporting components

DSPC DC57005 · 100 mg+Cholesterol DCD-041 · 100 mg+DMG-PEG2000 DC40169 · 100 mg

Components are supplied separately; this is not a premixed LNP. RNA/cargo, buffer and formulation service are not included.

Total$700

We match the best price and quality on market.

Ships from ShanghaiIce-pack transportPure lipid recommended

Product overview

Description & Application

ARV-T1 is an ionizable lipid investigated for intramuscular mRNA delivery. Its research LNP formulation showed prolonged reporter expression and enhanced antibody responses relative to the study SM-102 comparator, with supporting cell-viability and short-term mouse tolerability data.

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Literature evidence · DC67567

Formulation & Performance

Reporter kinetics, vaccine antibody responses, storage stability and tolerability are separate evidence endpoints.

Reported performance refers to the complete research formulation and the stated experimental model.

Formulation components and molecular-weight conversion

Component	DC Chemicals product	Molecular weight	Molar ratio	Mass at 1 µmol total lipid (mg)
ARV-T1	DC67567	910.51	50	0.455255
DSPC	DC57005	790.15	10	0.079015
Cholesterol	DCD-041	386.65	38.5	0.148860
DMG-PEG2000	DC40169	2507	1.5	0.037605

ARV-T1/DSPC/cholesterol/DMG-PEG2000 = 50:10:38.5:1.5 mol%; reported N/P = 4. Source: Methods, LNP formulation. DMG-PEG2000 uses 2507 for calculated component masses. A lipid:RNA mass ratio is not inferred from N/P.

Component mass calculator

Prefilled proportions follow the source specified above. Molecular weights and ratios are editable. Results are calculated, not measured study data. No N/P or RNA dose is inferred.

Total lipid (µmol)

Component	Mass (mg)	Mass %
ARV-T1	—	—
DSPC	—	—
Cholesterol	—	—
DMG-PEG2000	—	—

Particle properties

Experiment / parameter	Study conditions	Result / interpretation
Apparent pKa	TNS assay on LNPs without encapsulated mRNA; Fig. 2F	6.73; this is a formulation-dependent measurement, not an isolated-molecule pKa.
Hydrodynamic size	Fig. 2 and Discussion	Approximately 80 nm for ARV-T1 versus 90 nm for the SM-102 comparator.
Encapsulation	Fig. 2	Both formulations exceeded 90% RNA encapsulation.
Dispersity and surface potential	Fig. 2	ARV-T1 showed lower PDI and greater absolute zeta potential than the comparator; the text describes magnitudes of approximately 10 versus 5 mV.

Cellular expression and viability

Experiment / parameter	Study conditions	Result / interpretation
Protein expression	HEK293T cell experiments; Fig. 3	ARV-T1 LNPs produced higher antigen expression than the matched SM-102 formulation. No fold change is inferred from chart heights.
Cell viability	HEK293T and Huh7; 48 h; Fig. 7A	No significant reduction was reported across most tested concentrations; a high-concentration effect was observed in Huh7 at 125 µM.

Intramuscular reporter kinetics

Experiment / parameter	Study conditions	Result / interpretation
Study conditions	BALB/c mice, n = 6; 1 µg luciferase mRNA IM	Luminescence assessed at 6, 24, 48 and 72 h (Fig. 5).
ARV-T1 expression	Peak at 24 h	Approximately 50% of peak signal remained at 72 h.
SM-102 comparator	Peak at 6 h	Signal declined rapidly and was barely detectable at 72 h in this experiment.

Antibody responses

Experiment / parameter	Study conditions	Result / interpretation
Prime/boost study	Mouse immunization on days 1 and 21; readouts days 14 and 35; Fig. 6	The authors report >10-fold higher potency for antigen-binding and neutralizing-antibody responses compared with the study SM-102 formulation.
Dose-response interpretation	Low-dose vaccine comparisons	Antibody potency is not a measure of tenfold higher transfection in every tissue, and is not a human vaccine efficacy estimate.

Storage and in vivo tolerability

Experiment / parameter	Study conditions	Result / interpretation
Frozen storage	12 weeks at −20°C versus −80°C; Fig. 4C	Cellular protein expression was similar, although PDI increased at −20°C.
Refrigerated storage	12 weeks at 4°C; Fig. 4C	Approximately 50% fewer antigen-positive cells and 66% lower median fluorescence than the frozen groups.
Repeated IM administration	Two doses separated by three weeks; Fig. 7	Blood chemistry one day after the last dose and tissue histology two weeks later showed no reported abnormal changes; body weight was not significantly altered.
Scope	Study formulation and observation windows	The study does not establish human, chronic or unrestricted-dose safety. Storage findings do not define the isolated reagent shelf life.

Original study figures

Cell expression, storage, mouse expression and tolerability: Figures 3–7 — Original source figures.

References and source locations

CAS No.	Not available
Chemical Name	ARV-T1
Synonyms	ARVT1, ARV T1
SMILES	CCCCCCCCC(CCCCCC)OC(=O)CCCCCCN(CCCCO)CCCCCC(=O)O[C@H]1CC[C@@]2(C)C(=CC[C@@H]3[C@@H]2CC[C@@]2(C)[C@H]3CC[C@@H]2[C@H](C)CCCC(C)C)C1
Formula	C59H107NO5
M.Wt	910.51
Purity	>95% by ELSD-HPLC
Storage	Pure form: −20 °C, 1 year; In solvent: −80 °C, 6 months; −20 °C, 1 month. Sealed and protected from light.
Shipping condition	Ships from Shanghai. Pure lipid is stable during ice-pack transport.
Publication	Jeon JH, et al. Lipid Nanoparticles Formulated with a Novel Cholesterol-Tailed Ionizable Lipid Markedly Increase mRNA Delivery Both in vitro and in vivo. International Journal of Nanomedicine 20, 9389–9405 (2025). DOI: 10.2147/IJN.S527822. Full text: formulation Methods and Figures 2–7.

Laboratory planning

Solution Calculators

The product molecular weight is prefilled when available and remains editable. Confirm solvent compatibility and solubility before preparation.

N/P 4 is reported directly and is not converted into a mass ratio.

Mass = concentration × volume × molecular weight

MassConcentrationVolumeMolecular weightg/mol

Enter any three values to calculate the fourth.

C₁V₁ = C₂V₂

C₁mMV₁mLC₂mMV₂mL

Enter any three values to calculate the fourth.

Preparing stock solutions

Quick preparation table

Solvent volumes update from the molecular weight above.

Mass	1 mM	5 mM	10 mM
10 mg	10.9829 mL	2.1966 mL	1.0983 mL
25 mg	27.4571 mL	5.4914 mL	2.7457 mL
50 mg	54.9143 mL	10.9829 mL	5.4914 mL
100 mg	109.8286 mL	21.9657 mL	10.9829 mL
250 mg	274.5714 mL	54.9143 mL	27.4571 mL

Need a different pack size or technical document?

Contact our team with the catalog number and requested quantity.

Handling guidance

Shipping, storage and sampling

How is the lipid shipped, and how should I store it?

We generally ship the neat (undissolved) lipid compound rather than an ethanol solution. The neat lipid is stable during transport with ice packs, and shipments originate from Shanghai. Pure form: store at −20 °C for up to 1 year. In solvent: store at −80 °C for up to 6 months or at −20 °C for up to 1 month. Keep sealed and protected from light. Avoid repeated thaw cycles for best results.

Pure lipid or solution — which should I choose?

Pure lipid is generally more stable during shipping and storage, so we usually recommend the pure form. A solution in ethanol or chloroform can be supplied when required by your workflow. Tell us the intended application, solvent and target concentration so the most suitable format can be confirmed.

How should I measure a small amount of oily or viscous lipid?

Ionizable lipids are often oily liquids or viscous semisolids, so material can be lost during repeated weighing or transfer. For a small pack, dissolve the entire quantity and aliquot it volumetrically. For example, add 1 mL ethanol to 25 mg lipid to prepare a 25 mg/mL stock, then use a pipette to withdraw the required amount. For quantities above 100 mg, direct weighing with an analytical balance may be more practical. Always confirm solvent compatibility and solubility first.

Can you support formulation optimization and scale-up?

Yes. Share the RNA cargo, target tissue, administration route, formulation method and assay plan. Our team can discuss starting molar ratios, N/P ratio and scale-up requirements for research workflows.

ARV-T1

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