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Ionizable lipids / CAP 2 (hydrochloride)
CAP 2 (hydrochloride) chemical structure
Product imageResearch use only
CAT. NO. DC67476

CAP 2 (hydrochloride)

Ionizable lipid for LNP and nucleic-acid delivery research.

Pack size & price

USD
TotalPrice on request
We match the best price and quality on market.
Ships from ShanghaiIce-pack transportPure lipid recommended
Product overview

Description & Application

CAP 2 is a unique ionizable lipid featuring a bicholesterol structure connected by a phosphate linker with an amino terminus. This design enables efficient in vivo delivery of both mRNA and saRNA via LNPs. In a Dmc1-deficient mouse model of male infertility, saRNA-encoded Dmc1 delivered by CAP 2 LNPs demonstrated prolonged protein expression in testicular tissue compared to mRNA formulations. The treatment restored spermatogenesis, improving germ cell maturation, seminiferous tubule morphology, and ultimately yielding functional sperm capable of fertilization.

CAS No.Not available
Chemical NameCAP 2 (hydrochloride)
SynonymsCAP 2-4 Cholesterol-Amino-Phosphate 2
SMILESC[C@]12CC[C@@H](CC1=CC[C@@]3([C@@]2(CC[C@]4([C@]3(CC[C@]4([H])[C@@H](CCCC(C)C)C)[H])C)[H])[H])OP(O[C@H]5CC[C@@]6(C)C(C5)=CC[C@]7([H])[C@]6([H])CC[C@@]8(C)[C@@]7([H])CC[C@]8([H])[C@@H](CCCC(C)C)C)(OCCCN(C)C)=O.Cl
FormulaC59H102NO4P • HCl
M.Wt956.9
Purity>98%
StoragePure form: −20 °C, 1 year; In solvent: −80 °C, 6 months; −20 °C, 1 month. Sealed and protected from light.
Shipping conditionShips from Shanghai. Pure lipid is stable during ice-pack transport.
PublicationNot available
Laboratory planning

Solution Calculators

The product molecular weight is prefilled when available and remains editable. Confirm solvent compatibility and solubility before preparation.

Mass = concentration × volume × molecular weight
Enter any three values to calculate the fourth.
C₁V₁ = C₂V₂
Enter any three values to calculate the fourth.
Preparing stock solutions

Quick preparation table

Solvent volumes update from the molecular weight above.

Mass1 mM5 mM10 mM
10 mg10.4504 mL2.0901 mL1.0450 mL
25 mg26.1260 mL5.2252 mL2.6126 mL
50 mg52.2521 mL10.4504 mL5.2252 mL
100 mg104.5041 mL20.9008 mL10.4504 mL
250 mg261.2603 mL52.2521 mL26.1260 mL

Need a different pack size or technical document?

Contact our team with the catalog number and requested quantity.

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Handling guidance

Shipping, storage and sampling

How is the lipid shipped, and how should I store it?
We generally ship the neat (undissolved) lipid compound rather than an ethanol solution. The neat lipid is stable during transport with ice packs, and shipments originate from Shanghai. Pure form: store at −20 °C for up to 1 year. In solvent: store at −80 °C for up to 6 months or at −20 °C for up to 1 month. Keep sealed and protected from light. Avoid repeated thaw cycles for best results.
Pure lipid or solution — which should I choose?
Pure lipid is generally more stable during shipping and storage, so we usually recommend the pure form. A solution in ethanol or chloroform can be supplied when required by your workflow. Tell us the intended application, solvent and target concentration so the most suitable format can be confirmed.
How should I measure a small amount of oily or viscous lipid?
Ionizable lipids are often oily liquids or viscous semisolids, so material can be lost during repeated weighing or transfer. For a small pack, dissolve the entire quantity and aliquot it volumetrically. For example, add 1 mL ethanol to 25 mg lipid to prepare a 25 mg/mL stock, then use a pipette to withdraw the required amount. For quantities above 100 mg, direct weighing with an analytical balance may be more practical. Always confirm solvent compatibility and solubility first.
Can you support formulation optimization and scale-up?
Yes. Share the RNA cargo, target tissue, administration route, formulation method and assay plan. Our team can discuss starting molar ratios, N/P ratio and scale-up requirements for research workflows.