PRODUCT DATASHEET · DC67476
CAP 2 (hydrochloride)
Version 1.987b2b4f · 2026-09-13
| CAS No. | Not available |
| Chemical Name | CAP 2 (hydrochloride) |
| Synonyms | CAP 2-4 Cholesterol-Amino-Phosphate 2 |
| SMILES | C[C@]12CC[C@@H](CC1=CC[C@@]3([C@@]2(CC[C@]4([C@]3(CC[C@]4([H])[C@@H](CCCC(C)C)C)[H])C)[H])[H])OP(O[C@H]5CC[C@@]6(C)C(C5)=CC[C@]7([H])[C@]6([H])CC[C@@]8(C)[C@@]7([H])CC[C@]8([H])[C@@H](CCCC(C)C)C)(OCCCN(C)C)=O.Cl |
| Formula | C59H102NO4P • HCl |
| M.Wt | 956.9 |
| Purity | >98% |
| Storage | Original product: up to 1 year under the storage conditions stated on the vial, kept tightly sealed. Stock solutions: aliquots at -20°C, generally up to one month. |
| Shipping condition | Ships from Shanghai. Pure lipid is stable during ice-pack transport. |
| Publication | Not available |
CAP 2 is a unique ionizable lipid featuring a bicholesterol structure connected by a phosphate linker with an amino terminus. This design enables efficient in vivo delivery of both mRNA and saRNA via LNPs. In a Dmc1-deficient mouse model of male infertility, saRNA-encoded Dmc1 delivered by CAP 2 LNPs demonstrated prolonged protein expression in testicular tissue compared to mRNA formulations. The treatment restored spermatogenesis, improving germ cell maturation, seminiferous tubule morphology, and ultimately yielding functional sperm capable of fertilization.
Specifications shown are product-page values, not batch test results.
Read Instructions for Use →