DLin-MC3-DMA
Recommended because it shares a closely related research category or delivery context. Formulation and performance are product- and study-specific.
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Ionizable lipid for LNP and nucleic-acid delivery research.
2N12B is a redox-responsive cationic lipid (pKa = 6.5) designed for siRNA delivery. Its LNPs mediate robust VEGFA knockdown in both cultured retinal cells and ex vivo mouse retina, while functionally impairing HUVEC motility. When administered in retinopathy models, the nanoparticles alleviate disease hallmarks including abnormal vessel growth and retinal vascular leakage.
| CAS No. | Not available |
| Chemical Name | 2N12B |
| Synonyms | 2-N12B, 2N12-B, 2N-12B |
| SMILES | O=C(NCCN(C)C)C(CCSCCC(OCCCCCCCC(C)C)=O)NC(CCCCC(CCSCCC(OCCCCCC(C)C)=O)SCCC(OCCCCCC(C)C)=O)=O |
| Formula | C51H97N3O8S3 |
| M.Wt | 976.5 |
| Purity | >98% |
| Storage | Pure form: −20 °C, 1 year; In solvent: −80 °C, 6 months; −20 °C, 1 month. Sealed and protected from light. |
| Shipping condition | Ships from Shanghai. Pure lipid is stable during ice-pack transport. |
| Publication | Not available |
The product molecular weight is prefilled when available and remains editable. Confirm solvent compatibility and solubility before preparation.
Solvent volumes update from the molecular weight above.
| Mass | 1 mM | 5 mM | 10 mM |
|---|---|---|---|
| 10 mg | 10.2407 mL | 2.0481 mL | 1.0241 mL |
| 25 mg | 25.6016 mL | 5.1203 mL | 2.5602 mL |
| 50 mg | 51.2033 mL | 10.2407 mL | 5.1203 mL |
| 100 mg | 102.4066 mL | 20.4813 mL | 10.2407 mL |
| 250 mg | 256.0164 mL | 51.2033 mL | 25.6016 mL |
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