PRODUCT DATASHEET · DC67461
2N12B
Version 1.165c7623 · 2026-09-13
| CAS No. | Not available |
| Chemical Name | 2N12B |
| Synonyms | 2-N12B， 2N12-B， 2N-12B |
| SMILES | O=C(NCCN(C)C)C(CCSCCC(OCCCCCCCC(C)C)=O)NC(CCCCC(CCSCCC(OCCCCCC(C)C)=O)SCCC(OCCCCCC(C)C)=O)=O |
| Formula | C51H97N3O8S3 |
| M.Wt | 976.5 |
| Purity | >98% |
| Storage | Original product: up to 1 year under the storage conditions stated on the vial, kept tightly sealed. Stock solutions: aliquots at -20°C, generally up to one month. |
| Shipping condition | Ships from Shanghai. Pure lipid is stable during ice-pack transport. |
| Publication | Not available |
2N12B is a redox-responsive cationic lipid (pKa = 6.5) designed for siRNA delivery. Its LNPs mediate robust VEGFA knockdown in both cultured retinal cells and ex vivo mouse retina, while functionally impairing HUVEC motility. When administered in retinopathy models, the nanoparticles alleviate disease hallmarks including abnormal vessel growth and retinal vascular leakage.
Specifications shown are product-page values, not batch test results.
Read Instructions for Use →