LP-01
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Ionizable lipid for LNP and nucleic-acid delivery research.
Lipid 29 is an ionizable amino lipid (pKa = 6.91) from Moderna platform that has been used in combination with other lipids in the formation of lipid nanoparticles (LNPs).Administration of human erythropoietin (EPO) mRNA in lipid 29-containing LNPs increases serum EPO levels in mice.
| CAS No. | Not available |
| Chemical Name | Moderna Lipid 29 |
| Synonyms | Moderna Lipid-29 Lipid29,Lipid 29,-[[8-[(1-ethylnonyl)oxy]-8-oxooctyl][3-[[2-(methylamino)-3,4-dioxo-1-cyclobuten-1-yl]amino]propyl]amino]-octanoic acid, 1-octylnonyl ester |
| SMILES | CNC(C(C1=O)=O)=C1NCCCN(CCCCCCCC(OC(CCCCCCCC)CCCCCCCC)=O)CCCCCCCC(OC(CC)CCCCCCCC)=O |
| Formula | C52H97N3O6 |
| M.Wt | 860.4 |
| Purity | ELSD-HPLC>95% |
| Storage | Pure form: −20 °C, 1 year; In solvent: −80 °C, 6 months; −20 °C, 1 month. Sealed and protected from light. |
| Shipping condition | Ships from Shanghai. Pure lipid is stable during ice-pack transport. |
| Publication | Mark Cornebise, et al. Discovery of a Novel Amino Lipid That Improves Lipid Nanoparticle Performance through Specific Interactions with mRNA. Advanced functional materials. 2022. |
The product molecular weight is prefilled when available and remains editable. Confirm solvent compatibility and solubility before preparation.
Solvent volumes update from the molecular weight above.
| Mass | 1 mM | 5 mM | 10 mM |
|---|---|---|---|
| 10 mg | 11.6225 mL | 2.3245 mL | 1.1623 mL |
| 25 mg | 29.0563 mL | 5.8113 mL | 2.9056 mL |
| 50 mg | 58.1125 mL | 11.6225 mL | 5.8113 mL |
| 100 mg | 116.2250 mL | 23.2450 mL | 11.6225 mL |
| 250 mg | 290.5625 mL | 58.1125 mL | 29.0563 mL |
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