C18 NC-TNP
Recommended because it shares a closely related research category or delivery context. Formulation and performance are product- and study-specific.
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Ionizable lipid for LNP and nucleic-acid delivery research.
A3B7C2 is an imidazole‑based ionizable lipid, featuring dimethylamino‑imidazole head group connected via ester‑type degradable C2‑linker to two C14 unsaturated aliphatic tails. It forms LNPs achieving 98 % splenic transfection proportion, potent for splenic dendritic cell‑targeted mRNA delivery, superior to MC3, SM102.
| CAS No. | Not available |
| Chemical Name | Lipid A3B7C2 |
| Synonyms | A3B7C2 |
| SMILES | n1cn(CCN(CCO)CCO)c(-c2cc(OCCCCC(=O)OCCCCCCCCCCCC)c(OCCCCC(=O)OCCCCCCCCCCCC)cc2)c1-c1ccc2ccccc2c1 |
| Formula | C61H95N3O8 |
| M.Wt | 998.44 |
| Purity | >98% |
| Storage | Pure form: −20 °C, 1 year; In solvent: −80 °C, 6 months; −20 °C, 1 month. Sealed and protected from light. |
| Shipping condition | Ships from Shanghai. Pure lipid is stable during ice-pack transport. |
| Publication | Multicomponent Synthesis of Imidazole-Based Ionizable Lipids for Highly Efficient and Spleen-Selective Messenger RNA Delivery-Journal American Chemical Society (2024) 146 (22): 15085–15095. |
The product molecular weight is prefilled when available and remains editable. Confirm solvent compatibility and solubility before preparation.
Solvent volumes update from the molecular weight above.
| Mass | 1 mM | 5 mM | 10 mM |
|---|---|---|---|
| 10 mg | 10.0156 mL | 2.0031 mL | 1.0016 mL |
| 25 mg | 25.0391 mL | 5.0078 mL | 2.5039 mL |
| 50 mg | 50.0781 mL | 10.0156 mL | 5.0078 mL |
| 100 mg | 100.1562 mL | 20.0312 mL | 10.0156 mL |
| 250 mg | 250.3906 mL | 50.0781 mL | 25.0391 mL |
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