E10i-494
Recommended because it shares a closely related research category or delivery context. Formulation and performance are product- and study-specific.
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Ionizable lipid for LNP and nucleic-acid delivery research.
FTT5 LLNs is a modified TT3-derived lipidoid optimized for nucleic acid delivery via lipid-like nanoparticles (LLNs). These formulations demonstrate hepatic tropism in mice and enhance reporter gene expression in Hep3B cells. Therapeutically, FTT5 LLNs successfully deliver Factor VIII mRNA to restore clotting activity in hemophilic mice and enable in vivo genome editing applications.
| CAS No. | Not available |
| Chemical Name | FTT5 LLNs |
| Synonyms | Functionalized N1,N3,N5-tris(2-aminoethyl)benzene-1,3,5-Tricarboxamide 5,FTT5-LLNs, FTT5LLNs |
| SMILES | O=C(NCCCN(CCCCCCCCC(OC(CCCCC)CC)=O)CCCCCCCCC(OC(CCCCC)CC)=O)C1=CC(C(NCCCN(CCCCCCCCC(OC(CCCCC)CC)=O)CCCCCCCCC(OC(CCCCC)CC)=O)=O)=CC(C(NCCCN(CCCCCCCCC(OC(CCCCC)CC)=O)CCCCCCCCC(OC(CCCCC)CC)=O)=O)=C1 |
| Formula | C120H222N6O15 |
| M.Wt | 1,989.1 |
| Purity | >98% |
| Storage | Pure form: −20 °C, 1 year; In solvent: −80 °C, 6 months; −20 °C, 1 month. Sealed and protected from light. |
| Shipping condition | Ships from Shanghai. Pure lipid is stable during ice-pack transport. |
| Publication | Not available |
The product molecular weight is prefilled when available and remains editable. Confirm solvent compatibility and solubility before preparation.
Solvent volumes update from the molecular weight above.
| Mass | 1 mM | 5 mM | 10 mM |
|---|---|---|---|
| 10 mg | 5.0274 mL | 1.0055 mL | 502.74 μL |
| 25 mg | 12.5685 mL | 2.5137 mL | 1.2568 mL |
| 50 mg | 25.1370 mL | 5.0274 mL | 2.5137 mL |
| 100 mg | 50.2740 mL | 10.0548 mL | 5.0274 mL |
| 250 mg | 125.6850 mL | 25.1370 mL | 12.5685 mL |
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