DLin-MC3-DMA
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Ionizable lipid for LNP and nucleic-acid delivery research.
Lipid U 105 is an ionizable cationic lipid (pKa 6.65) specifically designed for circular RNA delivery via LNPs. These formulations effectively enhance VEGF-A expression in HUVECs, promoting endothelial cell proliferation and migration. When applied topically in diabetic mouse models, the VEGF-A-encoding circular RNA LNPs significantly accelerate wound healing, demonstrating therapeutic potential for impaired tissue repair.
| CAS No. | Not available |
| Chemical Name | Lipid U 105 |
| Synonyms | di(heptadecan-9-yl) 6,6'-((3-(bis(2-hydroxyethyl)amino)propyl)azanediyl)dihexanoate,Lipid-U-105, U105 |
| SMILES | CCCCCCCCC(CCCCCCCC)OC(CCCCCN(CCCCCC(OC(CCCCCCCC)CCCCCCCC)=O)CCCN(CCO)CCO)=O |
| Formula | C53H106N2O6 |
| M.Wt | 867.4 |
| Purity | >98% |
| Storage | Pure form: −20 °C, 1 year; In solvent: −80 °C, 6 months; −20 °C, 1 month. Sealed and protected from light. |
| Shipping condition | Ships from Shanghai. Pure lipid is stable during ice-pack transport. |
| Publication | Not available |
The product molecular weight is prefilled when available and remains editable. Confirm solvent compatibility and solubility before preparation.
Solvent volumes update from the molecular weight above.
| Mass | 1 mM | 5 mM | 10 mM |
|---|---|---|---|
| 10 mg | 11.5287 mL | 2.3057 mL | 1.1529 mL |
| 25 mg | 28.8218 mL | 5.7644 mL | 2.8822 mL |
| 50 mg | 57.6435 mL | 11.5287 mL | 5.7644 mL |
| 100 mg | 115.2871 mL | 23.0574 mL | 11.5287 mL |
| 250 mg | 288.2177 mL | 57.6435 mL | 28.8218 mL |
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