For research use only. We do not sell to patients.
Ionizable lipids / CP-LC-0729
CP-LC-0729 chemical structure
Product imageResearch use only
CAT. NO. DC66650

CP-LC-0729

Ionizable lipid for LNP and nucleic-acid delivery research.

Pack size & price

USD
TotalPrice on request
We match the best price and quality on market.
Ships from ShanghaiIce-pack transportPure lipid recommended
Product overview

Description & Application

Lipid CP-LC-0729, an ionizable cationic amino lipid synthesized from homocysteine—a naturally occurring amino acid—has been shown to exhibit superior efficacy in the delivery and subsequent protein expression of various RNA modalities, including messenger RNA (mRNA), circular RNA (cRNA), and self-amplifying RNA (saRNA) in vivo. Importantly, CP-LC-0729 demonstrates an exemplary safety profile, with no observable toxicological effects in preclinical studies. Comparative analyses reveal that CP-LC-0729 significantly surpasses MC3, a widely utilized benchmark lipid nanoparticle formulation, in terms of protein expression efficiency. Specifically, CP-LC-0729 achieves a striking 32-fold enhancement in protein expression within lung tissue relative to MC3, underscoring its pronounced tissue selectivity and targeting efficacy for pulmonary applications. These findings suggest that CP-LC-0729 represents a highly promising candidate for the development of RNA-based therapeutics, particularly in the context of lung-targeted delivery systems, where its combination of high efficiency and low toxicity offers significant translational potential.

CAS No.Not available
Chemical NameCP-LC-0729
SynonymsCPLC0729， CP LC 0729
SMILESO=C(C(NC(C(CCCCCCCC)CCCCCC)=O)CCSCCC(OCC(CCCCCCCC)CCCCCC)=O)NCCN(C)C
FormulaC43H85N3O4S
M.Wt740.2
PurityNot available
StoragePure form: −20 °C, 1 year; In solvent: −80 °C, 6 months; −20 °C, 1 month. Sealed and protected from light.
Shipping conditionShips from Shanghai. Pure lipid is stable during ice-pack transport.
PublicationNot available
Laboratory planning

Solution Calculators

The product molecular weight is prefilled when available and remains editable. Confirm solvent compatibility and solubility before preparation.

Mass = concentration × volume × molecular weight
Enter any three values to calculate the fourth.
C₁V₁ = C₂V₂
Enter any three values to calculate the fourth.
Preparing stock solutions

Quick preparation table

Solvent volumes update from the molecular weight above.

Mass1 mM5 mM10 mM
10 mg13.5099 mL2.7020 mL1.3510 mL
25 mg33.7747 mL6.7549 mL3.3775 mL
50 mg67.5493 mL13.5099 mL6.7549 mL
100 mg135.0986 mL27.0197 mL13.5099 mL
250 mg337.7466 mL67.5493 mL33.7747 mL

Need a different pack size or technical document?

Contact our team with the catalog number and requested quantity.

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Handling guidance

Shipping, storage and sampling

How is the lipid shipped, and how should I store it?
We generally ship the neat (undissolved) lipid compound rather than an ethanol solution. The neat lipid is stable during transport with ice packs, and shipments originate from Shanghai. Pure form: store at −20 °C for up to 1 year. In solvent: store at −80 °C for up to 6 months or at −20 °C for up to 1 month. Keep sealed and protected from light. Avoid repeated thaw cycles for best results.
Pure lipid or solution — which should I choose?
Pure lipid is generally more stable during shipping and storage, so we usually recommend the pure form. A solution in ethanol or chloroform can be supplied when required by your workflow. Tell us the intended application, solvent and target concentration so the most suitable format can be confirmed.
How should I measure a small amount of oily or viscous lipid?
Ionizable lipids are often oily liquids or viscous semisolids, so material can be lost during repeated weighing or transfer. For a small pack, dissolve the entire quantity and aliquot it volumetrically. For example, add 1 mL ethanol to 25 mg lipid to prepare a 25 mg/mL stock, then use a pipette to withdraw the required amount. For quantities above 100 mg, direct weighing with an analytical balance may be more practical. Always confirm solvent compatibility and solubility first.
Can you support formulation optimization and scale-up?
Yes. Share the RNA cargo, target tissue, administration route, formulation method and assay plan. Our team can discuss starting molar ratios, N/P ratio and scale-up requirements for research workflows.