For research use only. We do not sell to patients.
Ionizable lipids / Lipid H9
Lipid H9 chemical structure
CAT. NO. DC60466

Lipid H9

Pack size & price

USD
TotalPrice on request
We match the best price and quality on market.
Ships from ShanghaiIce-pack transportPure lipid recommended
Product overview

Description & Application

Lipid H9 is an ionizable lipid identified with the AGILE platform for mRNA delivery research. In the cited study, optimized H9 lipid nanoparticles delivered firefly-luciferase mRNA to mouse muscle after intramuscular injection, with a 7.8-fold higher local expression signal than the MC3 benchmark and a signal comparable to ALC-0315. The investigators also evaluated Cre mRNA delivery and an ovalbumin mRNA vaccination model.

CAS No.Not available
Chemical Name(Z)-5-(octadec-9-en-1-ylamino)-5-oxo-4-(piperidin-1-ylamino)pentyl octanoate
SynonymsLipid-H9
SMILESCCCCCCCC/C=C\CCCCCCCCNC(=O)C(CCCOC(=O)CCCCCCC)NN1CCCCC1
FormulaC36H69N3O3
M.Wt591.97
Purity>95% by ELSD-HPLC
StoragePure form: −20 °C, 1 year; In solvent: −80 °C, 6 months; −20 °C, 1 month. Sealed and protected from light.
Shipping conditionShips from Shanghai. Pure lipid is stable during ice-pack transport.
PublicationXu Y, et al. Nature Communications 15, 6305 (2024). DOI: 10.1038/s41467-024-50619-z
Laboratory planning

Solution Calculators

The product molecular weight is prefilled when available and remains editable. Confirm solvent compatibility and solubility before preparation.

Mass = concentration × volume × molecular weight
Enter any three values to calculate the fourth.
C₁V₁ = C₂V₂
Enter any three values to calculate the fourth.
Preparing stock solutions

Quick preparation table

Solvent volumes update from the molecular weight above.

Mass1 mM5 mM10 mM
10 mg16.8927 mL3.3785 mL1.6893 mL
25 mg42.2319 mL8.4464 mL4.2232 mL
50 mg84.4637 mL16.8927 mL8.4464 mL
100 mg168.9275 mL33.7855 mL16.8927 mL
250 mg422.3187 mL84.4637 mL42.2319 mL

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Handling guidance

Shipping, storage and sampling

How is the lipid shipped, and how should I store it?
We generally ship the neat (undissolved) lipid compound rather than an ethanol solution. The neat lipid is stable during transport with ice packs, and shipments originate from Shanghai. Pure form: store at −20 °C for up to 1 year. In solvent: store at −80 °C for up to 6 months or at −20 °C for up to 1 month. Keep sealed and protected from light. Avoid repeated thaw cycles for best results.
Pure lipid or solution — which should I choose?
Pure lipid is generally more stable during shipping and storage, so we usually recommend the pure form. A solution in ethanol or chloroform can be supplied when required by your workflow. Tell us the intended application, solvent and target concentration so the most suitable format can be confirmed.
How should I measure a small amount of oily or viscous lipid?
Ionizable lipids are often oily liquids or viscous semisolids, so material can be lost during repeated weighing or transfer. For a small pack, dissolve the entire quantity and aliquot it volumetrically. For example, add 1 mL ethanol to 25 mg lipid to prepare a 25 mg/mL stock, then use a pipette to withdraw the required amount. For quantities above 100 mg, direct weighing with an analytical balance may be more practical. Always confirm solvent compatibility and solubility first.
Can you support formulation optimization and scale-up?
Yes. Share the RNA cargo, target tissue, administration route, formulation method and assay plan. Our team can discuss starting molar ratios, N/P ratio and scale-up requirements for research workflows.