Selonsertib（GS-4997） chemical structure
Chemical structureResearch use only
CAT. NO. DC9873Featured

Selonsertib（GS-4997）

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TotalUS$450
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Product overview

Description & Application

Selonsertib is an apoptosis signal-regulating kinase 1 (ASK1) inhibitor with a pIC50 of 8.3±0.07.

ParameterValue
Chemical NameSelonsertib free base
CAS No.1448428-04-3
SynonymsGS-4997; GS4997; GS 4997; Selonsertib free base.
FormulaC24H24FN7O
M.Wt445.5
SMILESO=C(NC1=NC(C2=NN=CN2C(C)C)=CC=C1)C3=CC(N4C=C(C5CC5)N=C4)=C(C)C=C3F
Purity>98%

Biological Activity

Selonsertib is an apoptosis signal-regulating kinase 1 (ASK1) inhibitor with a pIC50 of 8.3±0.07.

In Vitro

Selonsertib (GS-4997) is a clinical stage ASK1 inhibitor, which has been evaluated as an experimental treatment for diabetic nephropathy and kidney fibrosis[1]. Selonsertib (GS-4997) is a highly selective and potent once-daily oral ASK1 inhibitor that competes with ATP in the ASK1 catalytic kinase domain[2].

In Vivo

No in vivo data are provided in the current product source. Contact us for further information.

References & source

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.

Product documentation

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