BI-7273 chemical structure
Chemical structureResearch use only
CAT. NO. DC9724Featured

BI-7273

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Product overview

Description & Application

BI-7273 is a potent, selective, and cell-permeable BRD9 BD Inhibitor with Kd (BRD9, ITC) = 15 nM and Kd (BRD9, DiscoveRx) = 0.75 nM. IC50 (BRD9 alpha assay ) = 19nm. BI-7273 proves to be invaluable as tools to further explore BRD9 biology. Components of the chromatin remodelling SWI/SNF complex are recurrently mutated in tumours, suggesting that altering the activity of the complex plays a role in oncogenesis. BRD9, a SWI/SNF subunit, play an important role in leukemia growth. The BRD9 bromodomain (BD) was shown to be required for the proliferation of acute myeloid leukemia (AML) cells.

ParameterValue
Chemical Name4-(4-((dimethylamino)methyl)-2,6-dimethoxyphenyl)-2-methyl-2,7-naphthyridin-1(2H)-one
SynonymsBI 7273,BI7273
FormulaC20H23N3O3
M.Wt353.41
SMILESO=C1N(C)C=C(C2=C(OC)C=C(CN(C)C)C=C2OC)C3=CC=NC=C13
Purity98%
Storage2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological Activity

BI-7273 is a potent, selective, and cell-permeable BRD9 BD Inhibitor with Kd (BRD9, ITC) = 15 nM and Kd (BRD9, DiscoveRx) = 0.75 nM. IC50 (BRD9 alpha assay ) = 19nm. BI-7273 proves to be invaluable as tools to further explore BRD9 biology. Components of the chromatin remodelling SWI/SNF complex are recurrently mutated in tumours, suggesting that altering the activity of the complex plays a role in oncogenesis. BRD9, a SWI/SNF subunit, play an important role in leukemia growth. The BRD9 bromodomain (BD) was shown to be required for the proliferation of acute myeloid leukemia (AML) cells.

In Vitro

No in vitro data are provided in the current product source. Contact us for further information.

In Vivo

No in vivo data are provided in the current product source. Contact us for further information.

References & source

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.

Product documentation

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Handling guide

2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Solution calculator

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