(+)-JQ1 PA chemical structure
Chemical structureResearch use only
CAT. NO. DC12021Featured

(+)-JQ1 PA

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Product overview

Description & Application

(+)-JQ1 PA is a derivative of the Bromodomain and extra-terminal (BET) inhibitor JQ1, with an IC50 of 10.4 nM.

ParameterValue
Chemical Name(+)-JQ1 PA
CAS No.2115701-93-2
Synonyms(+)-JQ1 PA;(S)-2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-N-(prop-2-yn-1-yl)acetamide;A936393;(6S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-N-2-propyn-1-yl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetamide;2-[(6S)-4-(4-Chlorophenyl)-;CID 134821687;JQ1 PA;JQ-1 PA;JQ 1 PA;PubChem ID: 134821687;6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetamide, 4-(4-chlorophenyl)-2,3,9-trimethyl-N-2-propyn-1-yl-, (6S)-;inhibit,(+) JQ1 PA,(+)-JQ1 PA,Inhibitor,Epigenetic Reader Domain,(+)JQ1 PA,(+)-JQ-1 PA;(S)-2-(4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-N-(prop-2-yn-1-yl)acetamide
FormulaC22H20ClN5OS
M.Wt437.945101737976
SMILESN12C(C)=NN=C1[C@H](CC(NCC#C)=O)N=C(C1=CC=C(Cl)C=C1)C1C(C)=C(C)SC=12
Purity>98%
Storage2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological Activity

(+)-JQ1 PA is a derivative of the Bromodomain and extra-terminal (BET) inhibitor JQ1, with an IC50 of 10.4 nM.

In Vitro

(+)-JQ1 PA is a derivative of JQ1, which is the inhibitor of BET. The IC50 of (+)-JQ1 PA for BET is 10.4 nM, and the IC50 of JQ1 is 14.3 nM in MV4;11 cells[1].

In Vivo

No in vivo data are provided in the current product source. Contact us for further information.

References & source

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.

Product documentation

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Handling guide

2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

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