Biological Activity
BI-7273 is a potent, selective, and cell-permeable BRD9 BD Inhibitor with Kd (BRD9, ITC) = 15 nM and Kd (BRD9, DiscoveRx) = 0.75 nM. IC50 (BRD9 alpha assay ) = 19nm. BI-7273 proves to be invaluable as tools to further explore BRD9 biology. Components of the chromatin remodelling SWI/SNF complex are recurrently mutated in tumours, suggesting that altering the activity of the complex plays a role in oncogenesis. BRD9, a SWI/SNF subunit, play an important role in leukemia growth. The BRD9 bromodomain (BD) was shown to be required for the proliferation of acute myeloid leukemia (AML) cells.
In Vitro
No in vitro data are provided in the current product source. Contact us for further information.
In Vivo
No in vivo data are provided in the current product source. Contact us for further information.
References & source
Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.