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Ionizable lipids / BAMP-TK-12
BAMP-TK-12 chemical structure
Product imageResearch use only
CAT. NO. DC82115Featured

BAMP-TK-12

Ionizable lipid for LNP and nucleic-acid delivery research.

Pack size & price

USD
TotalUS$800
We match the best price and quality on market.
Ships from ShanghaiIce-pack transportPure lipid recommended
Product overview

Description & Application

BAmP-TK-12 is a ROS-responsive ionizable lipid designed for tumor-cell mRNA delivery. It features a bis(aminopropyl)piperazine-derived ionizable headgroup and four C12 tails connected through cleavable thioketal linkers. In the reported study, BAmP-TK-12 achieved RFP expression in up to 95% of HeLa cells, comparable to Lipofectamine 3000, with lower cytotoxicity under the tested conditions. ROS-triggered linker cleavage supported intracellular mRNA release in high-ROS tumor cells. When formulated with DUF5 mRNA, the LNP suppressed tumor growth in HCT-116 and A549 xenograft models, supporting its use as a promising preclinical research lipid for stimulus-responsive mRNA delivery.

CAS No.Not available
Chemical NameBAMP-TK-12
SynonymsBAMP TK 12， BAMP-TK-12
SMILESCCCCCCCCCCCCOCCSC(C)(C)SCCOC(=O)CCNCCCN1CCN(CCCN(CCC(=O)OCCSC(C)(C)SCCOCCCCCCCCCCCC)CCC(=O)OCCSC(C)(C)SCCOCCCCCCCCCCCC)CC1
FormulaC76H150O9N4S6
M.Wt1,456.41
Purity>98%
StoragePure form: −20 °C, 1 year; In solvent: −80 °C, 6 months; −20 °C, 1 month. Sealed and protected from light.
Shipping conditionShips from Shanghai. Pure lipid is stable during ice-pack transport.
PublicationWeiqi Cai, Tianli Luo, Xianghan Chen, Lanqun Mao, and Ming Wang. “A Combinatorial Library of Biodegradable Lipid Nanoparticles Preferentially Deliver mRNA into Tumor Cells to Block Mutant RAS Signaling.” Advanced Functional Materials 2022, 32, 2204947.
Laboratory planning

Solution Calculators

The product molecular weight is prefilled when available and remains editable. Confirm solvent compatibility and solubility before preparation.

Mass = concentration × volume × molecular weight
Enter any three values to calculate the fourth.
C₁V₁ = C₂V₂
Enter any three values to calculate the fourth.
Preparing stock solutions

Quick preparation table

Solvent volumes update from the molecular weight above.

Mass1 mM5 mM10 mM
10 mg6.8662 mL1.3732 mL686.62 μL
25 mg17.1655 mL3.4331 mL1.7165 mL
50 mg34.3310 mL6.8662 mL3.4331 mL
100 mg68.6620 mL13.7324 mL6.8662 mL
250 mg171.6550 mL34.3310 mL17.1655 mL

Need a different pack size or technical document?

Contact our team with the catalog number and requested quantity.

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Handling guidance

Shipping, storage and sampling

How is the lipid shipped, and how should I store it?
We generally ship the neat (undissolved) lipid compound rather than an ethanol solution. The neat lipid is stable during transport with ice packs, and shipments originate from Shanghai. Pure form: store at −20 °C for up to 1 year. In solvent: store at −80 °C for up to 6 months or at −20 °C for up to 1 month. Keep sealed and protected from light. Avoid repeated thaw cycles for best results.
Pure lipid or solution — which should I choose?
Pure lipid is generally more stable during shipping and storage, so we usually recommend the pure form. A solution in ethanol or chloroform can be supplied when required by your workflow. Tell us the intended application, solvent and target concentration so the most suitable format can be confirmed.
How should I measure a small amount of oily or viscous lipid?
Ionizable lipids are often oily liquids or viscous semisolids, so material can be lost during repeated weighing or transfer. For a small pack, dissolve the entire quantity and aliquot it volumetrically. For example, add 1 mL ethanol to 25 mg lipid to prepare a 25 mg/mL stock, then use a pipette to withdraw the required amount. For quantities above 100 mg, direct weighing with an analytical balance may be more practical. Always confirm solvent compatibility and solubility first.
Can you support formulation optimization and scale-up?
Yes. Share the RNA cargo, target tissue, administration route, formulation method and assay plan. Our team can discuss starting molar ratios, N/P ratio and scale-up requirements for research workflows.