L-006,235

Biological Activity

L-006,235 is a potent, reversible cathepsin K inhibitor (IC50 = 0.25 nM) that displays > 4000-fold selectivity over cathepsins B, L and S. Displays reduced selectivity in cell-based assays possibly due to lysosomal accumulation. Reduces collagen breakdown and promotes bone deposition in vivo. Orally active and has intrinsic fluorescence. For the detailed information of L-006,235, the solubility of L-006,235 in water, the solubility of L-006,235 in DMSO, the solubility of L-006,235 in PBS buffer, the animal experiment (test) of L-006,235, the cell expriment (test) of L-006,235, the in vivo, in vitro and clinical trial test of L-006,235, the EC50, IC50,and affinity,of L-006,235, Please contact DC Chemicals.

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.