Biological Activity
Thymosin beta 4 is a potent regulator of actin polymerization in living cells. Sequence: Ser-Asp-Lys-Pro-Asp-Met-Ala-Glu-Ile-Glu-Lys-Phe-Asp-Lys-Ser-Lys-Leu-Lys-Lys-Thr-Glu-Thr-Gln-Glu-Lys-Asn-Pro-Leu-Pro-Ser-Lys-Glu-Thr-Ile-Glu-Gln-Glu-Lys-Gln-Ala-Gly-Glu-Ser.
In Vitro
As indicated by the significant reduction in the binding offluorescent phalloidin to injected cells, it is clear that (Thymosin beta 4 can induce an extensive depolymerization of actin filaments[1]. Treatment with the exogenous Thymosin beta 4 peptide inhibits the proliferation and migration of activated HSCs and reduces liver fibrosis.
In Vivo
No in vivo data are provided in the current product source. Contact us for further information.
Target
Actin
References & source
[1]. Sanders MC, et al. Thymosin beta 4 (Fx peptide) is a potent regulator of actin polymerization in living cells. Proc Natl Acad Sci U S A.
[2]. Kim J et al. Thymosin Beta 4 Is a Potential Regulator of Hepatic Stellate Cells. Vitam Horm.
Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.
