Thymosin beta 4 Datasheet | DC65642

Thymosin beta 4 — Datasheet

CAT. NO. DC65642

Parameter	Value
Chemical Name	Thymosin beta 4
CAS No.	77591-33-4
Synonyms	Fx Peptide; Thymosin Beta 4; Thymosin beta4; Thymosin β4 Acetate; Thymosin β4
Formula	C212H350N56O78S
M.Wt	4963.50
SMILES	NCCCCC(C(NC(C(NC(C(NC(C(NC(C(NC(C(NC(C(NC(C(NC(C(NC(C(NC(C(N1CCCC1C(NC(C(N1CCCC1C(NC(C(NC(C(NC(C(NC(C(NC(C(NC(C(NC(C(NC(C(NC(C(NC(C(NC(C(NCC(NC(C(NC(C(=O)O)CO)=O)CCC(=O)O)=O)=O)C)=O)CCC(=O)N)=O)CCCCN)=O)CCC(=O)O)=O)CCC(=O)N)=O)CCC(=O)O)=O)C(CC)C)=O)C(O)C)=O)CCC(=O)O)=O)CCCCN)=O)CO)=O)=O)CC(C)C)=O)=O)CC(=O)N)=O)CCCCN)=O)CCC(=O)O)=O)CCC(=O)N)=O)C(O)C)=O)CCC(=O)O)=O)C(O)C)=O)CCCCN)=O)CCCCN)=O)CC(C)C)=O)NC(C(NC(C(NC(C(NC(C(NC(C(NC(C(NC(C(NC(C(NC(C(NC(C(NC(C(NC(C1CCCN1C(C(NC(C(NC(C(NC(=O)C)CO)=O)CC(=O)O)=O)CCCCN)=O)=O)CC(=O)O)=O)CCSC)=O)C)=O)CCC(=O)O)=O)C(CC)C)=O)CCC(=O)O)=O)CCCCN)=O)CC1=CC=CC=C1)=O)CC(=O)O)=O)CCCCN)=O)CO)=O
Purity	>98%
Storage	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological Activity

Thymosin beta 4 is a potent regulator of actin polymerization in living cells. Sequence: Ser-Asp-Lys-Pro-Asp-Met-Ala-Glu-Ile-Glu-Lys-Phe-Asp-Lys-Ser-Lys-Leu-Lys-Lys-Thr-Glu-Thr-Gln-Glu-Lys-Asn-Pro-Leu-Pro-Ser-Lys-Glu-Thr-Ile-Glu-Gln-Glu-Lys-Gln-Ala-Gly-Glu-Ser.

In Vitro

As indicated by the significant reduction in the binding offluorescent phalloidin to injected cells, it is clear that (Thymosin beta 4 can induce an extensive depolymerization of actin filaments[1]. Treatment with the exogenous Thymosin beta 4 peptide inhibits the proliferation and migration of activated HSCs and reduces liver fibrosis.

In Vivo

No in vivo data are provided in the current product source. Contact us for further information.

Target

Actin

References & source

[1]. Sanders MC, et al. Thymosin beta 4 (Fx peptide) is a potent regulator of actin polymerization in living cells. Proc Natl Acad Sci U S A.

[2]. Kim J et al. Thymosin Beta 4 Is a Potential Regulator of Hepatic Stellate Cells. Vitam Horm.

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.