AZD-7624 chemical structure
Chemical structureResearch use only
CAT. NO. DC20242Featured

AZD-7624

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Product overview

Description & Application

AZD7624 is an inhaled p38 inhibitor, with potent anti-inflammatory activity.

ParameterValue
Chemical NameN-Cyclopropyl-3-fluoro-4-methyl-5-[3-[[1-[2-[2-(methylamino)ethoxy]phenyl]cyclopropyl]amino]-2-oxopyrazin-1-yl]benzamide
CAS No.1095004-78-6
SynonymsN-cyclopropyl-3-fluoro-4-methyl-5-[3-[[1-[2-[2-(methylamino)ethoxy]phenyl]cyclopropyl]amino]-2-oxo-1(2H)-pyrazinyl]-benzamide;AZD7624;3P4CR02JTD;AZD 7624 [WHO-DD];NNKPHNTWNILINE-UHFFFAOYSA-N;s8734;J3.631.182G;N-Cyclopropyl-3-fluoro-5-[3-[1-[2-[2-(methylamino)ethoxy]phenyl]cyclopropylamino]-2-oxo-1,2-dihydropyrazine-1-yl]-4-methylbenzamide;N-Cyclopropyl-3-fluoro-4-methyl-5-(3-((1-(2-(2-(methylamino)ethoxy)phenyl)cyclopropyl)amino)-2-oxopyrazin-1(2H)-yl)benzamide;N-Cyclopropyl-3-fluoro-4-methyl-5-[3-[[1-[2-[2-(methylamino)ethoxy]phenyl]cyclopropyl]a;N-Cyclopropyl-3-fluoro-4-methyl-5-[3-[[1-[2-[2-(methylamino)ethoxy]phenyl]cyclopropyl]amino]-2-oxopy
FormulaC27H30FN5O3
M.Wt491.5572
SMILESFC1=C([H])C(=C([H])C(=C1C([H])([H])[H])N1C([H])=C([H])N=C(C1=O)N([H])C1(C2=C([H])C([H])=C([H])C([H])=C2OC([H])([H])C([H])([H])N([H])C([H])([H])[H])C([H])([H])C1([H])[H])C(N([H])C1([H])C([H])([H])C1([H])[H])=O
Purity>98%
Storage2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological Activity

AZD7624 is an inhaled p38 inhibitor, with potent anti-inflammatory activity.

In Vitro

AZD7624 is an inhaled p38 inhibitor, with potent anti-inflammatory activity. AZD7624 inhibits LPS-induced TNFα in human mononuclear cells, in whole blood as well as in alveolar macrophages in vitro, with pIC50u of 8.4, 8.7, and 9.0[1].

In Vivo

No in vivo data are provided in the current product source. Contact us for further information.

References & source

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.

Product documentation

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Handling guide

2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

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