DC Chemicals · Product datasheet

AZD-7624 — Datasheet

CAT. NO. DC20242

Product page and current package options

ParameterValue
Chemical NameN-Cyclopropyl-3-fluoro-4-methyl-5-[3-[[1-[2-[2-(methylamino)ethoxy]phenyl]cyclopropyl]amino]-2-oxopyrazin-1-yl]benzamide
CAS No.1095004-78-6
SynonymsN-cyclopropyl-3-fluoro-4-methyl-5-[3-[[1-[2-[2-(methylamino)ethoxy]phenyl]cyclopropyl]amino]-2-oxo-1(2H)-pyrazinyl]-benzamide;AZD7624;3P4CR02JTD;AZD 7624 [WHO-DD];NNKPHNTWNILINE-UHFFFAOYSA-N;s8734;J3.631.182G;N-Cyclopropyl-3-fluoro-5-[3-[1-[2-[2-(methylamino)ethoxy]phenyl]cyclopropylamino]-2-oxo-1,2-dihydropyrazine-1-yl]-4-methylbenzamide;N-Cyclopropyl-3-fluoro-4-methyl-5-(3-((1-(2-(2-(methylamino)ethoxy)phenyl)cyclopropyl)amino)-2-oxopyrazin-1(2H)-yl)benzamide;N-Cyclopropyl-3-fluoro-4-methyl-5-[3-[[1-[2-[2-(methylamino)ethoxy]phenyl]cyclopropyl]a;N-Cyclopropyl-3-fluoro-4-methyl-5-[3-[[1-[2-[2-(methylamino)ethoxy]phenyl]cyclopropyl]amino]-2-oxopy
FormulaC27H30FN5O3
M.Wt491.5572
SMILESFC1=C([H])C(=C([H])C(=C1C([H])([H])[H])N1C([H])=C([H])N=C(C1=O)N([H])C1(C2=C([H])C([H])=C([H])C([H])=C2OC([H])([H])C([H])([H])N([H])C([H])([H])[H])C([H])([H])C1([H])[H])C(N([H])C1([H])C([H])([H])C1([H])[H])=O
Purity>98%
Storage2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological Activity

AZD7624 is an inhaled p38 inhibitor, with potent anti-inflammatory activity.

In Vitro

AZD7624 is an inhaled p38 inhibitor, with potent anti-inflammatory activity. AZD7624 inhibits LPS-induced TNFα in human mononuclear cells, in whole blood as well as in alveolar macrophages in vitro, with pIC50u of 8.4, 8.7, and 9.0[1].

In Vivo

No in vivo data are provided in the current product source. Contact us for further information.

References & source

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.

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