CeMMEC1 chemical structure
Chemical structureResearch use only
CAT. NO. DC9923Featured

CeMMEC1

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Product overview

Description & Application

CeMMEC1 is an inhibitor of BRD4, and also has high affinity for TAF1, with an IC50 of 0.9 μM for TAF1, and a Kd of 1.8 μM for TAF1 (2).

ParameterValue
Chemical NameCeMMEC1
CAS No.440662-09-9
SynonymsCeMMEC1;N-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methyl-1-oxo-1,2-dihydroisoquinoline-4-carboxamide;N-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-methyl-1-oxoisoquinoline-4-carboxamide;CeMMEC1 HCl;Oprea1_520920;BCP19839;STL155079;N-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-methyl-1-oxo-1,2-dihydroisoquinoline-4-carboxamide;cemmecl;CeMMEC1(free base);4-Isoquinolinecarboxamide, N-(2,3-dihydro-1,4-benzodioxin-6-yl)-1,2-dihydro-2-methyl-1-oxo-
FormulaC19H16N2O4
M.Wt336.350
SMILESO1CCOC2C=CC(=CC1=2)NC(C1=CN(C)C(C2C=CC=CC1=2)=O)=O
Purity>98%
Storage4°C for 1 year, -20°C for more than 2 years

Biological Activity

CeMMEC1 is an inhibitor of BRD4, and also has high affinity for TAF1, with an IC50 of 0.9 μM for TAF1, and a Kd of 1.8 μM for TAF1 (2).

In Vitro

CeMMEC1 is an inhibitor of BRD4, and also has high affinity for TAF1, with an IC50 of 0.9 μM for TAF1, and a Kd of 1.8 μM for TAF1 (2) and slso shows high affinity for the bromodomains of CREBBP, EP300, BRD9. CeMMEC1 (1, 10, 20 μM) decreases the number of THP1 cells in S phase in a dose manner. CeMMEC1 also induces apoptosis. CeMMEC1 in combination with (S)-JQ1 displays potently impaired cell viability than treatment alone[1].

In Vivo

No in vivo data are provided in the current product source. Contact us for further information.

References & source

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.

Product documentation

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Handling guide

4°C for 1 year, -20°C for more than 2 years

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